Alpha -1- Microglobulin (α1M) as an Early Biomarker in Renal Extrahepatic Manifestations of HCV-infection
NCT ID: NCT05276700
Last Updated: 2022-05-04
Study Results
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Basic Information
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UNKNOWN
170 participants
OBSERVATIONAL
2022-07-15
2024-03-31
Brief Summary
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Detailed Description
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HCV is both a consequence and cause of renal impairment: first, dialysis patients have an increased risk of infection related to medical procedures and, second, HCV causes pathological changes to the kidneys .
HCV seems to influence both renal tubular and glomerular cells as described by different proteinuria profiles and hematuria findings. Tubular cell damage may be the earliest sign of renal dysfunction caused by HCV and could potentially be used to identify patients with risk for progression. Routine urine analysis could be used to identify high risk HCV patients for early treatment.
Identifying patients early is of paramount importance in order to offer a prompt intervention and to improve the prognosis in both settings, for this purposes, novel biomarkers could be used One promising biomarker is alpha-1-microglobulin (α1m), a low molecular weight glycosylated protein of molecular weight synthesized by hepatocytes, freely filtered across the glomerulus, and then reabsorbed by the proximal tubule . it can signal proximal tubule dysfunction: higher Uα1m concentrations indicate impaired tubular reabsorption . Small studies have previously shown that Uα1m concentrations increase in Acute kidney injury (AKI), reflect severity of AKI, and are associated with the need for dialysis after nonoliguric AKI . Elevated Uα1m correlates with interstitial fibrosis and tubular atrophy on kidney biopsy, representing chronic kidney damage . Furthermore, Uα1m appears to predict kidney function decline and CKD progression , Acute kidney injury risk and also associated with early tubulointerstitial renal diseases in HCV-glomerulopathy .
Conditions
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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case with hcv
No interventions assigned to this group
control without hcv
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
3\. HCV-negative control at outpatients.
Exclusion Criteria
4\. patients with Active malignancy. 5. Alcoholics.
18 Years
65 Years
ALL
No
Sponsors
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Assiut University
OTHER
Responsible Party
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Ghada Safwat
principal investigator
Principal Investigators
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Enas Alkareemy
Role: STUDY_DIRECTOR
Assiut University
Central Contacts
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References
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Cacoub P, Comarmond C. Considering hepatitis C virus infection as a systemic disease. Semin Dial. 2019 Mar;32(2):99-107. doi: 10.1111/sdi.12758. Epub 2018 Dec 13.
Aguirre Valadez J, Garcia Juarez I, Rincon Pedrero R, Torre A. Management of chronic hepatitis C virus infection in patients with end-stage renal disease: a review. Ther Clin Risk Manag. 2015 Feb 27;11:329-38. doi: 10.2147/TCRM.S74282. eCollection 2015.
Kaartinen K, Vuoti S, Honkanen E, Loyttyniemi E, Singh R, Farkkila M. Tubular cell damage may be the earliest sign of renal extrahepatic manifestation caused by Hepatitis C. PLoS One. 2021 May 7;16(5):e0251392. doi: 10.1371/journal.pone.0251392. eCollection 2021.
Itoh Y, Kawai T. Human alpha 1-microglobulin: its measurement and clinical significance. J Clin Lab Anal. 1990;4(5):376-84. doi: 10.1002/jcla.1860040511.
Weber MH, Verwiebe R. Alpha 1-microglobulin (protein HC): features of a promising indicator of proximal tubular dysfunction. Eur J Clin Chem Clin Biochem. 1992 Oct;30(10):683-91.
Heise D, Rentsch K, Braeuer A, Friedrich M, Quintel M. Comparison of urinary neutrophil glucosaminidase-associated lipocalin, cystatin C, and alpha1-microglobulin for early detection of acute renal injury after cardiac surgery. Eur J Cardiothorac Surg. 2011 Jan;39(1):38-43. doi: 10.1016/j.ejcts.2010.05.044. Epub 2010 Jul 21.
Amer H, Lieske JC, Rule AD, Kremers WK, Larson TS, Franco Palacios CR, Stegall MD, Cosio FG. Urine high and low molecular weight proteins one-year post-kidney transplant: relationship to histology and graft survival. Am J Transplant. 2013 Mar;13(3):676-84. doi: 10.1111/ajt.12044. Epub 2013 Feb 15.
Bullen AL, Katz R, Lee AK, Anderson CAM, Cheung AK, Garimella PS, Jotwani V, Haley WE, Ishani A, Lash JP, Neyra JA, Punzi H, Rastogi A, Riessen E, Malhotra R, Parikh CR, Rocco MV, Wall BM, Bhatt UY, Shlipak MG, Ix JH, Estrella MM. The SPRINT trial suggests that markers of tubule cell function in the urine associate with risk of subsequent acute kidney injury while injury markers elevate after the injury. Kidney Int. 2019 Aug;96(2):470-479. doi: 10.1016/j.kint.2019.03.024. Epub 2019 May 7.
Other Identifiers
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α1M in HCV
Identifier Type: -
Identifier Source: org_study_id
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