BODY-Q Longitudinal Result Study and Comparison With Normative Scores

NCT ID: NCT05272215

Last Updated: 2022-03-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

20000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-06-30

Study Completion Date

2022-05-31

Brief Summary

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Obesity is a global epidemic that has nearly tripled since 1975. Worldwide, over 650 million people live with obesity, and it is therefore a growing cause for concern. Bariatric surgery (BaS) is the most effective long-term weight loss method in morbidly obese patients. BaS can result in sustained weight loss and resolve obesity-related comorbidities. However, BaS most often results in various extremes of excess skin, where subsequent body contouring surgery (BC) can be needed. The excess skin following massive weight loss is known to negatively impacts patients' body image, physical and psychological well-being, which previous studies have indicated to improve after BC.

The purpose of this study is to assess change in patients' health-related quality of life (HRQL) relative to the general population score. To the best of our knowledge, there are no studies measuring change of patient's HRQL throughout the entire weight loss journey and comparing these scores with the scores of the general population.

It is hypothesized that 1) BaS will improve patients' quality of life on short terms (1-2 years) after surgery, however patients' HRQL will decrease with increasing amounts of excess skin. 2) Patients' HRQL will improve after post-BC equivalent of the scores of the general population.

Detailed Description

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HRQL is best measured through patient-reported outcomes (PRO), defined as a patient evaluation of outcomes without interference from clinicians or any other intermediary. A vast array of patient-reported outcome measure (PROM)s have been used in weight loss and BC patients, many of which do not possess strong evidence of reliability and validity for the patient population.

In 2016, The BODY-Q, a condition-specific PROM developed following internationally recommended guidelines to measure PRO in weight loss, including bariatric surgery, and body contouring surgery (BC) patients were introduced. It consists of 32 independently functioning scales measuring four domains: appearance, HRQL, eating-related concerns, and patient experience of care. It is rigorously tested to ensure content validity, reliability, and responsiveness. Due to the strongest evidence for validity and its psychometric properties, recent systematic review based on the Consensus-based Standards for the selection of health Measurement Instruments (COSMIN) methodology only recommend the BODY-Q for use in this patient population.

The BODY-Q has been shown to be responsive to change and subsequently to measure change over the entire weight loss trajectory, i.e., from obesity to weight loss with or without BC. In previous studies, the BODY-Q has been used to demonstrate the efficacy of weight loss therapy and BC.

However, a current limitation of the BODY-Q is the lack of general population norms as a reference value of the four domains (HRQL, appearance, eating-related concerns, and experience of care). To date, it is not known how published preoperative and postoperative scores compare to population norms, enabling a better understanding of HRQL of obesity and change through the weight loss trajectory.

The primary aim of this study is to investigate the change of HRQL through the entire weight loss journey from obesity to post-BC in a longitudinal, prospective cohort study of Danish patients. The study will be performed as part of an international collaboration and Danish data will be merged with data from the Netherlands, Finland, Poland, Italy, Germany, and the United States. The secondary aim of this study is to compare international patient results with the general population norms. The general population norms. Currently, the general population norms study is under submission.

Conditions

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Weight Loss Excess Skin

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Patient group

Pre-BaS: Patients administered for BaS, Department of Endocrinology either Odense University Hospital, Odense, Denmark or Hospital of Southwest Jutland, Esbjerg, Denmark

Post-BaS: (3, 6, 12 months postoperatively, then yearly) Department of Surgery, Southwest Jutland, Esbjerg, Denmark

Pre-BC: Patients administered for BC, Department of Plastic Surgery, Odense University Hospital, Odense, Denmark or Department of Plastic Surgery, Southwest Jutland, Esbjerg, Denmark.

Post-BC: (3, 6, 12 months postoperatively, then yearly), department of Plastic Surgery, Odense University Hospital; Hospital of Southwest Jutland, Esbjerg.

Normative group: Reference scores of the general population from an international sample of 10 countries and country specific scores. This study sample is submitted for publication elsewhere.

Bariatric surgery

Intervention Type PROCEDURE

Pre- and post-bariatric surgery (3, 6, 12 months postoperative and yearly)

Body contouring surgery

Intervention Type PROCEDURE

Pre- and post body contouring surgery (3, 6, 12 months postoperative and yearly)

Interventions

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Bariatric surgery

Pre- and post-bariatric surgery (3, 6, 12 months postoperative and yearly)

Intervention Type PROCEDURE

Body contouring surgery

Pre- and post body contouring surgery (3, 6, 12 months postoperative and yearly)

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Pre- and post-bariatric surgery patients
* Pre- and post body contouring surgery patients
* Fluent in Danish

Exclusion Criteria

* Patients who do not speak Danish
* Patients with cognitive impairments
* Patients who have not undergone BaS/BC
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hospital of Southwest Jutland, Esbjerg, Denmark

UNKNOWN

Sponsor Role collaborator

McMaster University

OTHER

Sponsor Role collaborator

OLVG West Hospital, Amsterdam, the Netherlands

UNKNOWN

Sponsor Role collaborator

Catharina Ziekenhuis Eindhoven

OTHER

Sponsor Role collaborator

Tampere University Hospital

OTHER

Sponsor Role collaborator

Department of Plastic Surgery, Wroclaw, Poland

UNKNOWN

Sponsor Role collaborator

Department of Plastic Surgery, Eberhard Karls Universität Tübingen, Tübingen, Germany

OTHER

Sponsor Role collaborator

Campus Bio-Medico University

OTHER

Sponsor Role collaborator

Odense University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Farima Dalaei

MD

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Jens A Sørensen, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Odense University Hospital

Lotte Poulsen, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Odense University Hospital

Farima Dalaei, MD

Role: PRINCIPAL_INVESTIGATOR

Odense University Hospital

Locations

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Department of Plastic Surgery

Odense, Funen, Denmark

Site Status RECRUITING

Countries

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Denmark

Central Contacts

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Farima Dalaei, MD

Role: CONTACT

+45 28823662

Facility Contacts

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Jens A Sørensen, MD, PhD

Role: primary

+4522136707

Farima Dalaei, MD

Role: backup

+4528823662

Other Identifiers

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10240356

Identifier Type: -

Identifier Source: org_study_id

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