A Study Evaluating Safety, Tolerability and Clinical Activity of FHND6091 in Patients With Multiple Myeloma

NCT ID: NCT05271682

Last Updated: 2023-05-16

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: PHASE1
• Total Enrollment: 40 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2021-12-22
• Study Completion Date: 2024-12-31

Brief Summary

This is a phase I, first in human, single arm, open label study that will assess safety, tolerability and clinical activity of FHND6091 when taken orally on a weekly dosing schedule by patients with relapsed and refractory multiple myeloma (RRMM).The study will consist of two parts: dose escalation (Part 1) and dose expansion (Part 2).The dose escalation (Part 1) of the study will evaluate the safety and tolerability of FHND6091 using a dose escalation scheme to establish a maximum tolerated dose (MTD) and/or recommended Phase 2 dose (RP2D). And the dose expansion (Part B) of the study will further evaluate the safety, pharmacokinetics (PK)/ pharmacodynamics (PD), and efficacy of FHND6091 at two selected dose levels to characterize the safety, tolerability and efficacy of FHND6091.

A total of 40 evaluable participants will be enrolled in the study. The participants receiving treatment in part 1 and part 2 may continue combination treatment for a total of up to 12 cycles. After 12 cycles of therapy, the participants will continue treatment until the occurrence of PD, intolerable AEs, consent withdrawal, death or end of study based on the judgement of investigator's assessment.

Conditions

Multiple Myeloma

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: SEQUENTIAL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Part 1: 0.4 mg

FHND6091, 0.4 mg, capsules, orally, once weekly on Days 1, 8, and 15 of a 28-day cycle in the dose escalation period

Group Type: EXPERIMENTAL

FHND6091

Intervention Type: DRUG

FHND6091 capsules

Part 1: 0.8 mg

FHND6091, 0.8 mg, capsules, orally, once weekly on Days 1, 8, and 15 of a 28-day cycle in the dose escalation period

Group Type: EXPERIMENTAL

FHND6091

Intervention Type: DRUG

FHND6091 capsules

Part 1: 1.4 mg

FHND6091, 1.4 mg, capsules, orally, once weekly on Days 1, 8, and 15 of a 28-day cycle in the dose escalation period

Group Type: EXPERIMENTAL

FHND6091

Intervention Type: DRUG

FHND6091 capsules

Part 1: 2.0 mg

FHND6091, 2.0 mg, capsules, orally, once weekly on Days 1, 8, and 15 of a 28-day cycle in the dose escalation period

Group Type: EXPERIMENTAL

FHND6091

Intervention Type: DRUG

FHND6091 capsules

Part 1: 2.8 mg

FHND6091, 2.8 mg, capsules, orally, once weekly on Days 1, 8, and 15 of a 28-day cycle in the dose escalation period

Group Type: EXPERIMENTAL

FHND6091

Intervention Type: DRUG

FHND6091 capsules

Part 1: 3.6 mg

FHND6091, 3.6 mg, capsules, orally, once weekly on Days 1, 8, and 15 of a 28-day cycle in the dose escalation period

Group Type: EXPERIMENTAL

FHND6091

Intervention Type: DRUG

FHND6091 capsules

Part 2: lower dose expansion

FHND6091, a lower dose, capsules, orally, once weekly on Days 1, 8, and 15 of a 28-day cycle in the dose escalation period

Group Type: EXPERIMENTAL

FHND6091

Intervention Type: DRUG

FHND6091 capsules

Part 2: MTD pr MTD-1 dose expansion

FHND6091, MTD or MTD-1 dose, capsules, orally, once weekly on Days 1, 8, and 15 of a 28-day cycle in the dose escalation period

Group Type: EXPERIMENTAL

FHND6091

Intervention Type: DRUG

FHND6091 capsules

Interventions

FHND6091

FHND6091 capsules

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

• Patients must give written informed consent.
• Male or female patients 18 years or older.
• Eastern Cooperative Oncology Group (ECOG) Performance Status of 0, 1 or 2.
• Life expectancy of at least 12 weeks.
• Patients with multiple myeloma who have relapsed or refractory, intolerance or refuse treatment following at least 3 regimens or lines of therapy that must include an IMID (lenalidomide or thalidomide), a proteasome inhibitor (bortezomib) , a CD38-targeted mAbs and corticosteroids. Patients must have received transplant therapy or are not suitable for transplant.
• For Patients With Relapsed Refractory Multiple Myeloma must have measurable disease defined by at least 1 of the following 2 measurements: Serum M-protein ≥ 5 g/L, or Urine M-protein ≥ 200 mg/24 hours. For patients with serum free light chain as measurable disease: Serum immunoglobulin free light chain ≥10 mg/dL and abnormal serum immunoglobulin kappa to lambda free light chain ratio.
• Clinical laboratory values as specified below within 14 days before the first dose of study drug:

1. Hemoglobin ≥ 75 g/L, Absolute neutrophil count ≥ 1.0 x 10E9/L and Platelet count ≥ 75 x 10E9/L without blood transfusion, EPO or G-CSF and other medical support for at least 14 days prior to receiving screening.

2. Total bilirubin levels ≤ 2 x ULN, AST (SGOT) and ALT (SGPT) ≤ 2 x ULN.

3. Calculated or measured creatinine clearance (CrCl) of ≥ 30 mL/minute as calculated by Cockcroft-Gault method.

4. Corrected Serum Calcium ≤ ULN.

• For man and women of childbearing potential: agreement to remain abstinent or use contraception, during the treatment period (including treatment interruptions) and for at least 180 days after the last dose of FHND6091 was administered. Women of childbearing potential should be negative by serum pregnancy test within 7 days prior dosing.

Exclusion Criteria

• Documented allergy to proteasome inhibitor or ；
• Patients with peripheral neuropathy ≥ Grade 2 or Grade 1 peripheral neuropathy with pain.
• Patients with diarrhea > Grade 1 (Increase of <4 stools per day over baseline; mild increase in ostomy output compared to baseline).
• Patients received chemotherapy, radiation therapy, targeted therapy, immunotherapy or other systemic anticancer therapy within 14 days prior FHND6091 treatment.
• Patients received ixazomib treatment within 5 elimination half-life prior first dose of FHND6091 treatment.
• Patients received allogeneic stem cell transplantation or autologous stem cell transplant with 12 weeks before screening.
• Patients with symptomatic brain metastases, leptomeningeal metastases or, spinal cord compression or central nervous system (CNS) injuries/abnormalities based on investigator judgement.
• Evidence of severe or uncontrolled systemic diseases (eg, unstable or uncompensated respiratory, hepatic or renal disease), or receive major surgery.
• Patients with unstable hypertension after drug treatment (SBP ≥140 mmHg, DBP ≥90 mmHg ) or heart failure, myocardial ischemia or myocardial infarction, unstable angina, arrhythmia (The corrected QT interval (Fridericia formula) interval (QTcF) > 470 msec for females and > 450 msec for men in electrocardiogram (ECG)).
• Patients with active, or a history of immunodeficiency, including HIV positive or other acquired and congenital immunodeficiency diseases, or a history of solid organ transplant.
• Patients with a history of other serious underlying diseases, such as: a, history of a clear neurological or psychiatric disorder, including epilepsy or dementia. b, HBV surface antigen positivity (subjects with documented laboratory evidence of HBV clearance may be enrolled) or positive HCV antibody. c, presence of infection requiring systemic treatment.
• Systemic treatment with strong inhibitors of of CYP3A4 or strong CYP3A4 inducers within 5 elimination half-life prior first dose of FHND6091 treatment.
• Patients have not recovered (ie, ≤ Grade 1 toxicity by CTCAE 5.0) from the reversible effects of prior antineoplastic therapy (except for alopecia )
• Patients with other malignancy；
• Treatment with any investigational products within 28 days before the first dose of study treatment

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Jiangsu Chia Tai Fenghai Pharmaceutical Co., Ltd.

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Jianqin Mi, M.D.

Role: PRINCIPAL_INVESTIGATOR

Ruijin Hospital

Locations

The first affiliated hospital of bengbu medical college

Bengbu, Anhui, China

Site Status: RECRUITING

Henan Cancer Hospital

Zhengzhou, Henan, China

Site Status: RECRUITING

The Third Hosptial of Changsha

Changsha, Hunan, China

Site Status: RECRUITING

The Affilitated Hospital of Xuzhou Medical University

Xuzhou, Jiangsu, China

Site Status: RECRUITING

Xi'an Central Hospital

Xi'an, Shaanxi, China

Site Status: RECRUITING

Ruijin Hospital

Shanghai, , China

Site Status: RECRUITING

Countries

China

Central Contacts

Minghong Shang

Role: CONTACT

shangmh@ctfh.com.cn

025-57033246

Facility Contacts

Huan Zhou, Ph.D

Role: primary

13665527160

Yuefang Chen

Role: primary

hnszlyygcp@163.com

0371-65588007

Yu Cuihua

Role: primary

(0731) 8517 1463

Jiang Haijing

Role: primary

0516-23698580

Zhang Yi

Role: primary

029-81629000

Meiwen Shu

Role: primary

iec2020@rjh.com.cn

021-34188900

Other Identifiers

LWY20071C

Identifier Type: -

Identifier Source: org_study_id