Motivational Interviewing to Address Suicidal Ideation for Veterans at High Risk for Suicide

NCT ID: NCT05256940

Last Updated: 2026-01-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

470 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-11-30

Study Completion Date

2027-06-29

Brief Summary

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The purpose of this project is to conduct a randomized control trial with 470 Veterans to examine the impact of a revised version of Motivational Interviewing to Address Suicidal Ideation (MI-SI-R) on risk for suicide attempts and suicidal ideation when compared to high quality usual care.

Detailed Description

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Research suggests that treatments to reduce suicidal behavior may need to focus on both the motivation to live and the motivation to die to obtain optimal effects. The PI developed a revised version of Motivational Interviewing to Address Suicidal Ideation (MI-SI-R) to help Veterans resolve ambivalence about living by increasing the motivation to live, that consists of three sessions delivered in-person, virtually, or by telephone. Enhanced usual care (EUC) for high-risk Veterans includes safety plans administered or reviewed by research therapists, care coordination, and access to a 24-hour crisis hotline. In a preliminary randomized controlled trial (RCT) in psychiatrically hospitalized Veterans, MI-SI-R plus EUC was associated with 50% fewer suicide attempts and 41% lower likelihood of suicidal ideation compared to EUC alone. The investigators are proposing an RCT comparing MI-SI-R plus EUC (MI-SI-R+EUC) to EUC alone in a sample of 470 high-risk Veterans with recent suicidal crises from three VHA Medical Centers, with "high-risk" defined as a suicide attempt within a month or suicidal ideation \> 5 on the Beck Scale for Suicidal Ideation. Half (n = 235) will be randomized to MI-SI-R+EUC (three sessions in-person, via Video Connect, or telephone) and the remaining participants (n = 235) will receive EUC alone. All participants will be asked to complete telephone follow-up assessments at 1, 3, 6, and 12-months after randomization. This will allow the investigators to determine the efficacy of MI-SI-R+EUC in reducing risk for suicide attempts (Aim 1) and reducing overall suicidal ideation (Aim 2) when compared to EUC alone.

Conditions

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Suicide, Attempted Suicidal Ideation

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Motivational Interviewing to Address Suicidal Ideation (MI-SI-R) was developed to help participants at high-risk for suicide resolve their ambivalence about living by increasing their motivation to live, and is delivered in three sessions in-person, virtually, or by telephone.
Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors
Outcome assessors will be blinded to treatment received by participants.

Study Groups

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Motivational Interviewing to Address Suicidal Ideation- Revised (MI-SI-R)

Motivational Interviewing to Address Suicidal Ideation (MI-SI-R) was developed to help Veterans resolve ambivalence about living by increasing the motivation to live, and is delivered in three sessions in person, virtually, or by telephone.

Group Type EXPERIMENTAL

Motivational Interviewing to Address Suicidal Ideation- Revised (MI-SI-R)

Intervention Type BEHAVIORAL

Motivational Interviewing to Address Suicidal Ideation (MI-SI-R) was developed to help Veterans resolve ambivalence about living by increasing the motivation to live, that is delivered in three sessions in person, virtually, or by telephone.

Enhanced usual care (EUC)

Intervention Type OTHER

Enhanced usual care (EUC) includes safety plans administered or reviewed by research therapists, care coordination, and access to a 24-hour crisis hotline.

Enhanced usual care (EUC)

Enhanced usual care (EUC) includes safety plans administered or reviewed by research therapists, care coordination, and access to a 24-hour crisis hotline.

Group Type ACTIVE_COMPARATOR

Enhanced usual care (EUC)

Intervention Type OTHER

Enhanced usual care (EUC) includes safety plans administered or reviewed by research therapists, care coordination, and access to a 24-hour crisis hotline.

Interventions

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Motivational Interviewing to Address Suicidal Ideation- Revised (MI-SI-R)

Motivational Interviewing to Address Suicidal Ideation (MI-SI-R) was developed to help Veterans resolve ambivalence about living by increasing the motivation to live, that is delivered in three sessions in person, virtually, or by telephone.

Intervention Type BEHAVIORAL

Enhanced usual care (EUC)

Enhanced usual care (EUC) includes safety plans administered or reviewed by research therapists, care coordination, and access to a 24-hour crisis hotline.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Veteran status,
* admitted to an inpatient unit, referred by a suicide prevention coordinator, or identified as high-risk via data extraction,
* age 18 and over,
* English speaking and reading, and
* ability to understand the study and provide informed consent,
* high-risk status confirmed by suicide attempt within a month on the Columbia- Suicide Severity Rating Scale or a score \> 5 on the Scale for Suicidal Ideation

Exclusion Criteria

* current psychosis,
* active mania,
* dementia,
* impaired decision making capacity, and
* institutionalization due to hospitalization in a non-VA facility, jail, or prison.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Syracuse VA Medical Center

FED

Sponsor Role collaborator

Portland VA Medical Center

FED

Sponsor Role collaborator

Ralph H. Johnson VA Medical Center

FED

Sponsor Role collaborator

VA Office of Research and Development

FED

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Peter C. Britton, PhD MS

Role: PRINCIPAL_INVESTIGATOR

VA Finger Lakes Healthcare System, Canandaigua, NY

Locations

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VA Finger Lakes Healthcare System, Canandaigua, NY

Canandaigua, New York, United States

Site Status RECRUITING

VA Portland Health Care System, Portland, OR

Portland, Oregon, United States

Site Status RECRUITING

Ralph H. Johnson VA Medical Center, Charleston, SC

Charleston, South Carolina, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Richard J Servatius, PhD

Role: CONTACT

(315) 744-3370

Dorian L Savino, MPA

Role: CONTACT

(585) 463-2673

Facility Contacts

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Richard J Servatius, PhD

Role: primary

315-744-3370

Dorian L Savino, MPA

Role: backup

(585) 463-2673

David Cohen, MD

Role: primary

Sonemany Salinthone, PhD

Role: backup

Rutha Larue, PhD

Role: primary

Jesus Garcia, MS

Role: backup

Other Identifiers

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I01CX002359

Identifier Type: NIH

Identifier Source: secondary_id

View Link

MHBC-001-21S

Identifier Type: -

Identifier Source: org_study_id

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