Treat of Functional Ovarian Cysts by Compare Between Cocs and Progesterone Only Pills

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE3

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-02-20

Study Completion Date

2023-01-31

Brief Summary

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comparison between cocs and progesterone only containing pills in treatment of fuctional ovarian cyst

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Detailed Description

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Ovarian cyst is a blister-like sac, which is formed on the surface of ovary during or after ovulation . Most of them are made in reproductive age and are harmless ; these cysts do not cause any symptom and are resolved without treatment , but sometimes they cause health problems that require special attention, and even may lead to infertility. Normal function of ovary is the periodic release of ovums and the production of the steroid hormones of estradiol and progesterone . Both activities are integrated in the continuous repetitive process of follicle maturation, ovulation, and corpus luteum formation and regression. Mature follicle is ruptured and releases ovum during ovulation and corpus luteum is produced from empty follicle if pregnancy does not occur corpus luteum is regressed, due to the absence of hCG (human chorionic gonadotropin). Sometimes this procedure does not happen normally, which results in the formation of ovarian cysts Therefore, functional ovarian cysts are different from ovarian growths induced by other pathological problems most of them regress spontaneously in two or three cycles , but if a cyst gets large, it can twist, be ruptured, or bleed and become very painful .

A functional type of ovarian cyst forms because of slight changes in the way of making or releasing an ovum by the ovary . There are two types of such cysts:

1. The follicular cyst, which occurs when the sac on ovary does not release an egg and the sac swells up with fluid
2. The luteal cyst, which is formed when the sac releases an egg and then reseals and fills with fluid

Most functional ovarian cysts are asymptomatic , the larger the cyst, the more likely the symptom. The symptoms are pain or aching in lower abdomen, menstrual irregularity, vaginal bleeding, dyspareunia, etc.; sometimes the cyst is ruptured and causes peritoneal irritation with presentations such as nausea and vomiting or sudden onset of pain, hemorrhagic cyst, intra-abdominal bleeding, and emergency conditions . Some other manifestations such as nausea and vomiting may be felt before the occurrence of such events . Regular pelvic examination is recommended for some patients with the history of such cysts; they also may need regular sonography . Oral contraceptive pills (OCPs) are prescribed by some physician to shrink the cyst, if it is persistent and makes discomfort . Although it seems that they are not effective enough compared with close observation, and even some researchers reported no benefits for OCPs, some others prescribed them before any surgical practices ; therefore, the current study aimed at evaluating this issue. For this purpose, some patients who referred to a private clinic were selected in order to compare the effect of OCPs with close observation in the clinical management of functional ovarian cysts. dyspareunia, or the cysts may be found accidentally on voluntary sonography without any symptoms.

Conditions

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Ovarian Neoplasms

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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use of placebo in treatment of functional ovarian cyst

trial the effect of placebo in treatment of functional ovarian cyst

Group Type PLACEBO_COMPARATOR

Combined Oral Contraceptive

Intervention Type DRUG

effect of cocs in treatment of ovarian cysts

Progestin

Intervention Type DRUG

effect of progestin in treatment of ovarian cystn

use of cocs in treatment of functional ovarian cyst

trial of the effectiveness of cocs in the treatment of functional ovarian cyst

Group Type ACTIVE_COMPARATOR

Combined Oral Contraceptive

Intervention Type DRUG

effect of cocs in treatment of ovarian cysts

Progestin

Intervention Type DRUG

effect of progestin in treatment of ovarian cystn

use of progesterone in treatment of functional ovarian cyst

comparison between the effect of progesterone in the treatment of functional ovarian cyst with the effect of cocs

Group Type ACTIVE_COMPARATOR

Combined Oral Contraceptive

Intervention Type DRUG

effect of cocs in treatment of ovarian cysts

Progestin

Intervention Type DRUG

effect of progestin in treatment of ovarian cystn

Interventions

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Combined Oral Contraceptive

effect of cocs in treatment of ovarian cysts

Intervention Type DRUG

Progestin

effect of progestin in treatment of ovarian cystn

Intervention Type DRUG

Other Intervention Names

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cyclo progynova primalot-nor

Eligibility Criteria

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Inclusion Criteria

* The current randomized, clinical trial was performed on females with:-

1. functional ovarian cysts (4 to 8 cm in diameter)
2. in reproductive age, within the age range of 18 to 48 years, referred to the Clinic of Gynecological Diseases in a private hospital as outpatient The cysts were identified by transvaginal ultrasonography

Exclusion Criteria

* were history of:-

1. endometrioma.
2. Other non-functional .ovarian neoplasm
3. OCPs consumption during the last three months The patients were randomly divided into three equals

Minimum Eligible Age

18 Years

Maximum Eligible Age

48 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No