A Study to Compare the Drug Levels of Atazanavir and Cobicistat Between the Coadministration of Age-Appropriate Mini-Tablet Formulations and the Coadministration of the Individual Reference Products in Healthy Adults Under Fed Conditions

NCT ID: NCT05236738

Last Updated: 2022-10-31

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

42 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-05-13

Study Completion Date

2022-07-26

Brief Summary

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The purpose of this study is to evaluate the drug absorption of atazanavir and cobicistat between the coadministration of the mini-tablet formulations in applesauce or chocolate pudding followed by water and the coadministration of atazanavir oral powder in applesauce and cobicistat oral tablet followed by water in healthy adult participants.

Detailed Description

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Conditions

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Healthy Participants

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Treatment Sequence Group 1

Group Type EXPERIMENTAL

Atazanavir

Intervention Type DRUG

Specified dose on specified days

Cobicistat

Intervention Type DRUG

Specified dose on specified days

Atazanavir/Cobicistat Mini-tablet

Intervention Type DRUG

Specified dose on specified days

Treatment Sequence Group 2

Group Type EXPERIMENTAL

Atazanavir

Intervention Type DRUG

Specified dose on specified days

Cobicistat

Intervention Type DRUG

Specified dose on specified days

Atazanavir/Cobicistat Mini-tablet

Intervention Type DRUG

Specified dose on specified days

Treatment Sequence Group 3

Group Type EXPERIMENTAL

Atazanavir

Intervention Type DRUG

Specified dose on specified days

Cobicistat

Intervention Type DRUG

Specified dose on specified days

Atazanavir/Cobicistat Mini-tablet

Intervention Type DRUG

Specified dose on specified days

Interventions

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Atazanavir

Specified dose on specified days

Intervention Type DRUG

Cobicistat

Specified dose on specified days

Intervention Type DRUG

Atazanavir/Cobicistat Mini-tablet

Specified dose on specified days

Intervention Type DRUG

Other Intervention Names

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ATV Reyataz COBI Tybost Evotaz

Eligibility Criteria

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Inclusion Criteria

• Body Mass Index (BMI) of 18.0 to 32.0 kg/m\^2, inclusive. BMI = weight (kg)/\[height(m)\]\^2

Exclusion Criteria

* Significant acute or chronic medical illness
* History of a clinically significant drug rash, Stevens-Johnson Syndrome or Gilbert's Syndrome
* Inability to swallow oral medication
* Major surgery within 4 weeks of study treatment administration
Minimum Eligible Age

18 Years

Maximum Eligible Age

49 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Bristol-Myers Squibb

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Bristol-Myers Squibb

Role: STUDY_DIRECTOR

Bristol-Myers Squibb

Locations

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Local Institution - 0001

Miami, Florida, United States

Site Status

Countries

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United States

Related Links

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Other Identifiers

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AI424-578

Identifier Type: -

Identifier Source: org_study_id

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