A Study to Examine the Acceptable Taste and to Estimate the Amount of Atazanavir and Cobicistat in the Body When Taken as a Combination Product Versus When Taken as Separate Products at the Same Time

NCT ID: NCT04263350

Last Updated: 2021-11-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

34 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-02-26

Study Completion Date

2020-11-17

Brief Summary

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The purpose of this study is to compare the amount of Atazanavir (ATV) and Cobicistat (COBI) in the bodies of healthy adult participants when taken as a combination formulation, and when ATV is administered as an oral powder at the same time as COBI administered as an oral tablet. The ATV/COBI combination formulation and ATV powder will be taken with food.

Detailed Description

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Conditions

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Healthy Participants

Keywords

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Healthy Participants

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Treatment A:Fixed- dose combination mini-tablet

Group Type EXPERIMENTAL

Atazanavir/Cobicistat

Intervention Type DRUG

Specified Dose on Specified Days

Treatment B: Separate products taken at the same time

Group Type EXPERIMENTAL

Reyataz Atazanavir

Intervention Type DRUG

Specified Dose on Specified Days

Cobicistat

Intervention Type DRUG

Specified Dose on Specified Days

Interventions

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Atazanavir/Cobicistat

Specified Dose on Specified Days

Intervention Type DRUG

Reyataz Atazanavir

Specified Dose on Specified Days

Intervention Type DRUG

Cobicistat

Specified Dose on Specified Days

Intervention Type DRUG

Other Intervention Names

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ATV/COBI REYATAZ (ATV) COBI

Eligibility Criteria

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Inclusion Criteria

* Body mass index (BMI) of 18.0 to 32.0 kg/m2, inclusive.
* Women and men must agree to follow specific methods of contraception, if applicable.

Exclusion Criteria

* History of a clinically significant drug rash or Stevens-Johnson Syndrome
* History of Gilbert's Syndrome
* Current or recent (within 3 months of administration) gastrointestinal disease that could impact upon the absorption of study treatment
* Any major surgery within 4 weeks of study treatment administration
* Any gastrointestinal surgery that could impact upon the absorption of study treatment
Minimum Eligible Age

18 Years

Maximum Eligible Age

49 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Bristol-Myers Squibb

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Bristol-Myers Squibb

Role: STUDY_DIRECTOR

Bristol-Myers Squibb

Locations

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PPD Development, LP

Austin, Texas, United States

Site Status

Countries

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United States

Related Links

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Other Identifiers

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AI424-567

Identifier Type: -

Identifier Source: org_study_id