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Effect of Daytime Variation on Postoperative Hyperalgesia Induced by Opioids

NCT ID: NCT05234697

Last Updated: 2022-12-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

60 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-01-12

Study Completion Date

2022-05-20

Brief Summary

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To explore the effect of daytime variation on postoperative hyperalgesia induced by opioids. Patients receiving endoscopy surgery under general anesthesia during 08:00-12:00(morning group, n=30) and 14:00-18:00(afternoon group, n=30) using remifentanil for anesthesia maintenance were respectively included. Postoperative hyperalgesia at PACU and 24 hours after surgery were assessed through mechanical pain measurement. Comparative analysis of postoperative hyperalgesia levels, pain and analgesic requirements between morning group and afternoon group were performed.

Detailed Description

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Conditions

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Postoperative Hyperalgesia

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Morning group

Surgery performed during 08:00 to 12:00

Remifentanil

Intervention Type DRUG

Remifentanil was used for maintenance of anesthesia.

Afternoon group

Surgery performed during 14:00 to 18:00

Remifentanil

Intervention Type DRUG

Remifentanil was used for maintenance of anesthesia.

Interventions

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Remifentanil

Remifentanil was used for maintenance of anesthesia.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* American Society of Anesthesiologists classification I-II
* Abdominal endoscopy surgery
* Estimated surgery duration 1-2h
* Right handedness
* Voluntarily receive postoperative intravenous controlled analgesia

Exclusion Criteria

* Heavy smoking or alcohol dependence
* Puerpera or lactation women
* History of chronic pain
* Analgesic use within one month before surgery
* Allergy to opioids
* Can not follow with the study procedure
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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The Second Affiliated Hospital of Chongqing Medical University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Department of Anesthesiology, The Second Affiliated Hospital, Chongqing Medical University

Chongqing, Chongqing Municipality, China

Site Status

Countries

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China

References

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Shu B, Liu H, Zheng X, He J, Wu Y, Chen J, Chen Y, Tian H, Ju D, Huang H, Duan G. Opioid infusions at different times of the day produce varying degrees of opioid-induced hyperalgesia. Br J Anaesth. 2023 Dec;131(6):1072-1081. doi: 10.1016/j.bja.2023.08.039. Epub 2023 Oct 9.

Reference Type DERIVED
PMID: 37821342 (View on PubMed)

Other Identifiers

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Postoperative hyperalgesia

Identifier Type: -

Identifier Source: org_study_id