Artificial Intelligence System for the Detection and Prediction of Kidney Diseases Using Ocular Information

NCT ID: NCT05223712

Last Updated: 2022-02-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

4000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-08-28

Study Completion Date

2022-12-31

Brief Summary

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This is an retrospective and prospective multicenter study to develop and validate an artificial intelligent (AI) aided diagnosis, therapeutic effect assessment model including chronic kidney disease (CKD) and dialysis patients starting from April 2009, which is based on ophthalmic examinations (e.g. retinal fundus photography, slit-lamp images, OCTA, etc.) and CKD diagnostic and therapeutic data (routine clinical evaluations and laboratory data), to provide a reliable basis and guideline for clinical diagnosis and treatment.

Detailed Description

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Conditions

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Artificial Intelligence Ophthalmology Kidney Diseases

Study Design

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Observational Model Type

COHORT

Study Time Perspective

OTHER

Study Groups

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Development Dataset 01

Slit-lamp, retinal fundus images, OCTA and kidney diseases examinations collected from Department of Nephrology of the First Affiliated Hospital of Sun Yat-sen University

Diagnostic Test: Chronic Kidney Diseases

Intervention Type OTHER

The development datasets were used to train the deep learning model, which was validated and tested by the other 4 datasets.

Development Dataset 02

Slit-lamp, retinal fundus images, OCTA and kidney diseases examinations collected from Medical Centre of Aikang Health Care, Guangzhou, China

Diagnostic Test: Chronic Kidney Diseases

Intervention Type OTHER

The development datasets were used to train the deep learning model, which was validated and tested by the other 4 datasets.

Validation Dataset 01

Slit-lamp, retinal fundus images, OCTA and kidney diseases examinations collected from Department of Nephrology of the First Affiliated Hospital of Sun Yat-sen University

Diagnostic Test: Chronic Kidney Diseases

Intervention Type OTHER

The development datasets were used to train the deep learning model, which was validated and tested by the other 4 datasets.

Validation Dataset 02

Slit-lamp, retinal fundus images, OCTA and kidney diseases examinations collected from Medical Centre of Aikang Health Care, Guangzhou, China

Diagnostic Test: Chronic Kidney Diseases

Intervention Type OTHER

The development datasets were used to train the deep learning model, which was validated and tested by the other 4 datasets.

Test Dataset 01

Slit-lamp, retinal fundus images, OCTA and kidney diseases examinations collected from Department of Nephrology of the First Affiliated Hospital of Sun Yat-sen University

Diagnostic Test: Chronic Kidney Diseases

Intervention Type OTHER

The development datasets were used to train the deep learning model, which was validated and tested by the other 4 datasets.

Test Dataset 02

Slit-lamp, retinal fundus images, OCTA and kidney diseases examinations collected from Medical Centre of Aikang Health Care, Guangzhou, China

Diagnostic Test: Chronic Kidney Diseases

Intervention Type OTHER

The development datasets were used to train the deep learning model, which was validated and tested by the other 4 datasets.

Interventions

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Diagnostic Test: Chronic Kidney Diseases

The development datasets were used to train the deep learning model, which was validated and tested by the other 4 datasets.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Patients previously received kidney biopsy, ophthalmic examinations and routine examinations of the department of nephrology during in-hospital period with BCVA\>0.5.

Exclusion Criteria

* Patients without retinal fundus images or kidney diseases.
* The quality of the retinal fundus images can not meet the requirement for furthur analysis.
* Severe loss of results of routine examinations of the department of nephrology.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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First Affiliated Hospital, Sun Yat-Sen University

OTHER

Sponsor Role collaborator

Sun Yat-sen University

OTHER

Sponsor Role lead

Responsible Party

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Haotian Lin

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Yizhi Liu, M.D., Ph.D.

Role: STUDY_CHAIR

Zhongshan Ophthalmic Center, Sun Yat-sen University

Locations

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Zhongshan Ophthalmic Center, Sun Yat-sen University

Guangzhou, Guangdong, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Haotian Lin, Ph. D

Role: CONTACT

13802793086

Facility Contacts

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Haotian Lin, M.D., Ph.D

Role: primary

+8613802793086

Qianni Wu, M.D., Ph.D

Role: backup

+8615521506995

Other Identifiers

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AIKD-2021

Identifier Type: -

Identifier Source: org_study_id

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