Computational Neuroscience of Language Processing in the Human Brain
NCT ID: NCT05222594
Last Updated: 2026-01-20
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
40 participants
INTERVENTIONAL
2021-04-02
2026-03-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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NA
SINGLE_GROUP
BASIC_SCIENCE
NONE
Study Groups
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Epileptic participants undergoing intracranial monitoring
Patients with pharmaco-resistant epilepsy undergoing intracranial monitoring involving the left cerebral hemisphere.
Behavioral tasks during intracranial monitoring
Participants will listen to sentences and stories while neural data are recorded through electrodes placed for clinical purposes.
Interventions
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Behavioral tasks during intracranial monitoring
Participants will listen to sentences and stories while neural data are recorded through electrodes placed for clinical purposes.
Eligibility Criteria
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Inclusion Criteria
* the ability to comply with test directions and provide informed consent
* between ages 18 - 85
Exclusion Criteria
18 Years
85 Years
ALL
No
Sponsors
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Massachusetts Institute of Technology
OTHER
Massachusetts General Hospital
OTHER
Responsible Party
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Robert Mark Richardson
Director, Functional Neurosurgery
Locations
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Massachusetts General Hospital
Boston, Massachusetts, United States
Countries
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Central Contacts
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Facility Contacts
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References
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Blank I, Balewski Z, Mahowald K, Fedorenko E. Syntactic processing is distributed across the language system. Neuroimage. 2016 Feb 15;127:307-323. doi: 10.1016/j.neuroimage.2015.11.069. Epub 2015 Dec 5.
Blank IA, Fedorenko E. No evidence for differences among language regions in their temporal receptive windows. Neuroimage. 2020 Oct 1;219:116925. doi: 10.1016/j.neuroimage.2020.116925. Epub 2020 May 11.
Fedorenko E, Behr MK, Kanwisher N. Functional specificity for high-level linguistic processing in the human brain. Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16428-33. doi: 10.1073/pnas.1112937108. Epub 2011 Sep 1.
Fedorenko E, Blank IA. Broca's Area Is Not a Natural Kind. Trends Cogn Sci. 2020 Apr;24(4):270-284. doi: 10.1016/j.tics.2020.01.001. Epub 2020 Feb 20.
Fedorenko E, Duncan J, Kanwisher N. Language-selective and domain-general regions lie side by side within Broca's area. Curr Biol. 2012 Nov 6;22(21):2059-62. doi: 10.1016/j.cub.2012.09.011. Epub 2012 Oct 11.
Fedorenko E, Hsieh PJ, Nieto-Castanon A, Whitfield-Gabrieli S, Kanwisher N. New method for fMRI investigations of language: defining ROIs functionally in individual subjects. J Neurophysiol. 2010 Aug;104(2):1177-94. doi: 10.1152/jn.00032.2010. Epub 2010 Apr 21.
Fedorenko E, Nieto-Castanon A, Kanwisher N. Lexical and syntactic representations in the brain: an fMRI investigation with multi-voxel pattern analyses. Neuropsychologia. 2012 Mar;50(4):499-513. doi: 10.1016/j.neuropsychologia.2011.09.014. Epub 2011 Sep 17.
Fedorenko E, Scott TL, Brunner P, Coon WG, Pritchett B, Schalk G, Kanwisher N. Neural correlate of the construction of sentence meaning. Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):E6256-E6262. doi: 10.1073/pnas.1612132113. Epub 2016 Sep 26.
Mollica F, Siegelman M, Diachek E, Piantadosi ST, Mineroff Z, Futrell R, Kean H, Qian P, Fedorenko E. Composition is the Core Driver of the Language-selective Network. Neurobiol Lang (Camb). 2020 Mar 1;1(1):104-134. doi: 10.1162/nol_a_00005. eCollection 2020.
Nieto-Castanon A, Fedorenko E. Subject-specific functional localizers increase sensitivity and functional resolution of multi-subject analyses. Neuroimage. 2012 Nov 15;63(3):1646-69. doi: 10.1016/j.neuroimage.2012.06.065. Epub 2012 Jul 8.
Norman-Haignere S, Kanwisher NG, McDermott JH. Distinct Cortical Pathways for Music and Speech Revealed by Hypothesis-Free Voxel Decomposition. Neuron. 2015 Dec 16;88(6):1281-1296. doi: 10.1016/j.neuron.2015.11.035.
Pereira F, Lou B, Pritchett B, Ritter S, Gershman SJ, Kanwisher N, Botvinick M, Fedorenko E. Toward a universal decoder of linguistic meaning from brain activation. Nat Commun. 2018 Mar 6;9(1):963. doi: 10.1038/s41467-018-03068-4.
Shain C, Blank IA, van Schijndel M, Schuler W, Fedorenko E. fMRI reveals language-specific predictive coding during naturalistic sentence comprehension. Neuropsychologia. 2020 Feb 17;138:107307. doi: 10.1016/j.neuropsychologia.2019.107307. Epub 2019 Dec 24.
Siegelman M, Blank IA, Mineroff Z, Fedorenko E. An Attempt to Conceptually Replicate the Dissociation between Syntax and Semantics during Sentence Comprehension. Neuroscience. 2019 Aug 10;413:219-229. doi: 10.1016/j.neuroscience.2019.06.003. Epub 2019 Jun 11.
Other Identifiers
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2020P001989
Identifier Type: -
Identifier Source: org_study_id
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