Prevention of Opioid-induced Constipation in Patients With Advanced Cancer

NCT ID: NCT05216328

Last Updated: 2024-11-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

PHASE4

Total Enrollment

330 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-12-02

Study Completion Date

2025-12-31

Brief Summary

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More than 70% of patients with cancer in the palliative phase have pain that often requires treatment with opioids (morphine-like agents). Constipation occurs in 59% of patients treated with opioids. Opioid-induced constipation (OIC) has consequences that range from daily discomfort with social insecurity and disability to intestinal obstruction. It leads to limitations in self-management, a reduced quality of life and a risk of the need for more care. In the guideline "Diagnosis and treatment of pain in patients with cancer" it is recommended to start preventively with an osmotic laxative such as macrogol/electrolytes or magnesium hydroxide when starting opioids. Macrogol/electrolytes has been proven to be effective for OIC, but is sometimes perceived by patients as unpleasant due to its taste. Magnesium hydroxide, which is less commonly prescribed for OIC, has a neutral taste. Although it is mentioned in the guideline, it is not studied for the treatment of OIC and also not officially registered for this. To support the advice of the guideline and to prove that a choice is possible, it is important to investigate whether there are differences in effectiveness and/or side effects between macrogol/electrolytes and magnesium hydroxide in the prevention of OIC.

The aim of this study is to compare macrogol/electrolytes with magnesium hydroxide in the prevention of opioid-induced constipation in patients with cancer in the palliative (incurable) phase, who start opioids because of pain. The choice of laxative is determined by drawing lots (randomisation). After two weeks, its effect will be assessed and will be presented as the percentage of patients who have not developed constipation after starting opioids. If the laxative, as assigned by lot, is described as satisfactory by the patient, the patient can continue with the drug that the patient used, after the study through regular prescription.

The investigators will ask the patients in the study about their satisfaction with the laxative used, any side effects and the degree of pain. Furthermore, the appeal to care for possible constipation will be examined. Because the best attainable quality of life in the palliative phase is the objective of all care, the investigators will also measure this perceived quality with a questionnaire in this study. The results of this study will lead to the best achievable prevention of opioid constipation in patients with cancer in the palliative phase.

Detailed Description

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Conditions

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Constipation, Opioid-Induced

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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Macrogol/electrolytes

Macrogol/electrolytes is started at a dose of 1 sachet once a day orally, based on the current guideline 'Diagnosis and treatment of pain in patients with cancer' (www.pallialine.nl). The dose of macrogol/electrolytes may be increased to 2 sachets a day during the study period.

The effect of laxatives will be judged after 14 days.

Group Type ACTIVE_COMPARATOR

Macrogol Only Product in Oral Dose Form

Intervention Type DRUG

Information already included in arm/group description.

Magnesium hydroxide

Magnesium hydroxide is started at a dose of 724 mg three times a day orally, based on the current guideline 'Diagnosis and treatment of pain in patients with cancer' (www.pallialine.nl). The dose of magnesium hydroxide may be increased to 1448 mg three times a day during the study period. The effect of laxatives will be judged after 14 days.

Group Type ACTIVE_COMPARATOR

Magnesium hydroxide 724mg

Intervention Type DRUG

Information already included in arm/group description.

Interventions

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Macrogol Only Product in Oral Dose Form

Information already included in arm/group description.

Intervention Type DRUG

Magnesium hydroxide 724mg

Information already included in arm/group description.

Intervention Type DRUG

Other Intervention Names

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Macrogol/electrolytes Magnesiumoxide

Eligibility Criteria

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Inclusion Criteria

In order to be eligible to participate in this study, a subject must meet all of the following criteria:

* Patients with metastatic cancer (≥18 years);
* Starting with slow release or transdermal opioids for pain;
* Able to complete a Dutch questionnaire. Previous treatment with opioids is allowed, if discontinued more than 4 weeks ago.

Exclusion Criteria

A potential subject who meets any of the following criteria will be excluded from participation in this study:

* Patients with contra-indications for laxatives
* Use of laxatives during the last four weeks
* Severely impaired renal function (serum creatinine \>180 umol/l)
* Estimated life expectancy \<3 months
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Leiden University Medical Center

OTHER

Sponsor Role collaborator

University Medical Center Groningen

OTHER

Sponsor Role collaborator

Radboud University Medical Center

OTHER

Sponsor Role collaborator

Erasmus Medical Center

OTHER

Sponsor Role collaborator

Spaarne Gasthuis

OTHER

Sponsor Role collaborator

Rijnstate Hospital

OTHER

Sponsor Role collaborator

Jeroen Bosch Ziekenhuis

OTHER

Sponsor Role collaborator

Flevoziekenhuis

OTHER

Sponsor Role collaborator

Martini Hospital Groningen

OTHER

Sponsor Role collaborator

Haaglanden Medical Centre

OTHER

Sponsor Role collaborator

UMC Utrecht

OTHER

Sponsor Role collaborator

Groene Hart Ziekenhuis

OTHER

Sponsor Role collaborator

Bernhoven Hospital

OTHER

Sponsor Role collaborator

Isala

OTHER

Sponsor Role collaborator

Antoni van Leeuwenhoekziekenhuis (AVL) Amsterdam

UNKNOWN

Sponsor Role collaborator

Amsterdam UMC, location VUmc

OTHER

Sponsor Role lead

Responsible Party

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Lia van Zuylen

Prof. Dr.

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Lia van Zuylen, Prof.dr.

Role: PRINCIPAL_INVESTIGATOR

Amsterdam UMC, location VUmc

Locations

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Flevoziekenhuis

Almere Stad, Flevoland, Netherlands

Site Status RECRUITING

Rijnstate Ziekenhuis

Arnhem, Gelderland, Netherlands

Site Status RECRUITING

Radboud university Medical center Nijmegen

Nijmegen, Gelderland, Netherlands

Site Status RECRUITING

Jeroen Bosch Ziekenhuis

's-Hertogenbosch, North Brabant, Netherlands

Site Status RECRUITING

Amsterdam UMC, location VUmc

Amsterdam, North Holland, Netherlands

Site Status RECRUITING

Spaarne Gasthuis

Hoofddorp, North Holland, Netherlands

Site Status RECRUITING

Groene Hart Hospital

Gouda, South Holland, Netherlands

Site Status RECRUITING

Leiden University Medical Center

Leiden, South Holland, Netherlands

Site Status RECRUITING

Erasmus Medical Center

Rotterdam, South Holland, Netherlands

Site Status RECRUITING

Haaglanden Medical Centre

The Hague, South Holland, Netherlands

Site Status RECRUITING

University Medical Center Groningen

Groningen, , Netherlands

Site Status RECRUITING

Martini Hospital Groningen

Groningen, , Netherlands

Site Status RECRUITING

University Medical Center Utrecht

Utrecht, , Netherlands

Site Status RECRUITING

Countries

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Netherlands

Central Contacts

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Kay Kistemaker, MSc/MD

Role: CONTACT

+31 6 50087799

Lia van Zuylen, Prof. dr.

Role: CONTACT

+3120 4445571

Facility Contacts

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Dirkje Sommeijer, Dr.

Role: primary

Maurice van der Vorst, Drs.

Role: primary

Kris Vissers, Prof. dr

Role: primary

+31-24-3666353

Evelien Kuip, Dr.

Role: backup

+31-24-36592857

Tineke Smilde, Dr.

Role: primary

Monique Steegers, Prof. dr.

Role: primary

+31 (0)20 444 4444

Gerty de Klerk, Drs.

Role: primary

Marissa Cloos-van Balen, MD

Role: primary

Marije Slingerland, Dr.

Role: primary

Karin van der Rijt, Prof. dr.

Role: primary

Anouk Jochems, MD

Role: primary

AN Reyners, Prof. dr.

Role: primary

+31 50 361 28 21

Annette van der Velden, Dr.

Role: primary

Filip de Vos, Dr.

Role: primary

+31-88-7556265

Alexander de Graeff, Dr.

Role: backup

+31-88-7556308

References

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Related Links

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http://www.pallialine.nl

guidelines palliative care

http://www.palliaweb.nl

The Dutch digital palliative care platform

Other Identifiers

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08440012010002

Identifier Type: -

Identifier Source: org_study_id

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