Acquisition and Long-term Observation of Patients With Severe Allergic Reactions

NCT ID: NCT05210543

Last Updated: 2024-08-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

20000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2007-01-01

Study Completion Date

2030-12-31

Brief Summary

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The Anaphylaxis Registry aims to assess data in a standardized form about symptoms, triggers, cofactors and therapy management from patients who experienced an anaphylactic reaction. This should improve diagnosis and long-term management of these life-threatening allergic reactions.

Detailed Description

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A better understanding of the triggers and pathology of anaphylactic reactions could lead to a better diagnosis and prophylaxis to avoid the occurence of these life-threatening allergic reactions. This can be an advantage for affected persons regarding the their treatment and long-term management.

The Anaphylaxis Registry is an opportunity to gather these standardized data. The blood sampling is optional for the patient, however, it will contribute to the better understanding of the sensitization profile and possible mechanisms. Recent publications showed a correlation between an anaphylactic reaction and certain biomarkers. Those data will be validated in a larger number of population with identification of further biomarkers. It is presumed that certain genetic and epigenetic polymorphisms are abundant for patients who experienced an anaphylaxis.

To summarize, this study aims to contribute to a better understanding of the anaphylaxis in general, the diagnosis, and the prognosis with different severities. With the identification of a certain trigger, the obtained understanding may help to decrease the risk of or prevent future repeating reactions.

Conditions

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Anaphylaxis

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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Anaphylactic reaction (observational)

Patients who experienced an anaphylactic reaction will be observed

not applicable, observational study

Intervention Type OTHER

Patients do not receive intervention; observational study

Interventions

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not applicable, observational study

Patients do not receive intervention; observational study

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Anaphylactic reaction within the past 12 months

Exclusion Criteria

\-
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Charite University, Berlin, Germany

OTHER

Sponsor Role lead

Responsible Party

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Margitta Worm

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Margitta Worm, Prof.

Role: STUDY_CHAIR

Charite University, Berlin, Germany

Locations

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Charité - Universitätsmedizin Berlin

Berlin, , Germany

Site Status RECRUITING

Countries

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Germany

Central Contacts

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Margitta Worm, Prof.

Role: CONTACT

+49 30 450 518105

Sabine Dölle-Bierke, PhD

Role: CONTACT

+49 30 450 518367

Facility Contacts

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Margitta Worm, Prof.

Role: primary

+49 30 450 518105

Sabine Dölle-Bierke, PhD

Role: backup

+49 30 450 518367

Other Identifiers

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Anaphylaxis Registry

Identifier Type: -

Identifier Source: org_study_id

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