Chemo-free BRCA-targeted Neoadjuvant Strategy

NCT ID: NCT05209529

Last Updated: 2024-02-23

Basic Information

• Recruitment Status: WITHDRAWN
• Clinical Phase: PHASE2
• Study Classification: INTERVENTIONAL
• Study Start Date: 2024-02-01
• Study Completion Date: 2030-07-18

Brief Summary

This is a multicenter randomized phase ll clinical trial to evaluate the pathological complete response (pCR) in the tumour burden (primary and lymph nodes) with olaparib alone or in the olaparib and durvalumab arm in TNBC patients candidate for neoadjuvant strategy showing a t/gBRCAmut or BRCAness/HRD profile.

Detailed Description

Eligible patients will be registered for central testing of BRCA mutatinal status and HRD/BRCAness profile with central review of ER, PgR, TILs and PD-L1.

Eligible patients will be randomly assigned to either olparib or olaparib and durvalumab (=neoadjuvant treatment) in a 1:1 ratio. The treatment duration in both arms will last 16 weeks and both treatments are considered as experimental treatments in this study.

After completion of neoadjuvant systemic treatment, patients will undergo surgery and followed-up for 2 years after investigational drug discontinuation. After surgery, adjuvant treatment will be left at the investigator's decision.

Conditions

TNBC - Triple-Negative Breast Cancer; BRCA1 Mutation; BRCA2 Mutation

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Olaparib

Olaparib treatment for a total of 16 weeks

Group Type: EXPERIMENTAL

olaparib

Intervention Type: DRUG

olaparib 300 mg per os BID

Olaparib and durvalumab

Olaparib and durvalumab treatment for a total of 16 weeks

Group Type: EXPERIMENTAL

olaparib

Intervention Type: DRUG

olaparib 300 mg per os BID

Durvalumab

Intervention Type: DRUG

durvalumab 1500 mg IV Q4 weeks

Interventions

olaparib

olaparib 300 mg per os BID

Intervention Type: DRUG

Durvalumab

durvalumab 1500 mg IV Q4 weeks

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

• Histologically confirmed, invasive TNBC, defined as:

• ER and PR negative (not eligible for endocrine therapy) defined as immunohistochemistry (IHC) nuclear staining ≤ 10% AND
• HER2 negative (not eligible for anti-HER2 therapy):
• Early-stage disease, defined as cT1c-T2, N0-N1, M0
• Medically fit for a neoadjuvant strategy and for radical surgery as by the investigator's decision
• No prior systemic therapy nor definitive surgery for BC
• Age ≥18 years
• Women and men can be included
• ECOG performance status (PS) 0-1

• Deleterious germline or somatic mutation in BRCA 1 and/or BRCA 2 or homologue repair deficiency (HRD) status as determined by central testing.
• Tumour tissue available from primary tumour (fine needle aspiration cytology or lymph node metastasis tissue are not acceptable).
• Normal organ and bone marrow function measured within 28 days prior to administration of study treatment as defined below:

• Haemoglobin ≥ 10.0 g/dL with no blood transfusion in the past 28 days
• Absolute neutrophil count (ANC) ≥ 1.5 x 109/L
• Platelet count ≥ 100 x 109/L
• AST (SGOT) and ALT (SGPT) ≤ 2.5 x ULN
• Total bilirubin ≤ 1.5 x ULN (exception: higher bilirubin in patients with confirmed Gilbert's syndrome are allowed according to the investigator's decision)
• Creatinine clearance estimated of ≥ 51 mL/min/1.73m2 using the MDRD equation
• Body weight >30 kg
• Participation in translational research is mandatory
• Women of childbearing potential (WOCBP) must have a negative serum pregnancy test in the screening period and confirmed prior to treatment on day 1.
• Female patients of childbearing/reproductive potential must use adequate birth control measures, as defined by the investigator, during the study treatment period and for at least 3 months after the last dose of treatment. A highly effective method of birth control is defined as a method which results in a low failure rate (i.e., less than 1% per year) when used consistently and correctly. Such methods include:

• Intrauterine device (IUD)
• Intrauterine hormone-releasing system (IUS)
• Bilateral tubal occlusion
• Vasectomized partner
• Sexual abstinence (the reliability of sexual abstinence needs to be evaluated in relation to the duration of the clinical trial and the preferred and usual lifestyle of the patient)
• Male patients must use a condom during treatment and for 3 months after the last dose of study treatment when having sexual intercourse with a pregnant woman or with a woman of childbearing potential. Female partners of male patients should also use a highly effective form of contraception (see above) if they are of childbearing potential.
• Female subjects who are breast feeding must discontinue nursing prior to the first dose of study treatment and until 3 months after the last study treatment.
• Registration to a National Health Care System

Exclusion Criteria

• Previous treatment with a PARPi
• Previous treatment with an anti-PD-1/PD-L1, anti-PD-L2 or anti-CTLA-4 antibody
• Evidence of macroscopic distant metastases, investigated according to local institutional guidelines
• Patients who underwent sentinel node biopsy before neoadjuvant therapy
• History of previous invasive BC
• Bilateral and/or multifocal and/or multicentric BC
• Malabsorption syndrome or other chronic condition that would significantly interfere with enteral absorption
• History of allogenic transplantation of bone marrow or an organ.
• History of another primary malignancy.
• Myelodysplastic syndrome/acute myeloid leukaemia or features suggestive of such.
• Congenital long QT syndrome.
• History of active primary immunodeficiency

• Inability to swallow and/or retain oral tablets
• Blood transfusion within 28 days
• History of human immunodeficiency virus (HIV) (positive HIV 1/2-antibodies)
• Active Hepatitis B or Hepatitis C
• Active bacterial, viral, or fungal infection requiring systemic therapy
• History of active tuberculosis (TB, Bacillus Tuberculosis)
• History of idiopathic pulmonary fibrosis, drug-induced pneumonitis, organizing pneumonia, interstitial lung disease or evidence of active pneumonitis on screening (TAP-CT-scan)
• History of aortic disease (aneurysm or dissection)
• History of myasthenia gravis
• Mean QT interval corrected for heart rate (QTc) ≥ 500ms using Fridericia's Correction
• Uncontrolled intercurrent illness
• Psychiatric illness/social situations or addiction (chronic alcoholism or drug addiction) that would limit compliance with study requirement, substantially increase risk of incurring AEs or compromise the ability of the patient to give written informed consent.
• Any other serious or uncontrolled illness or abnormality that, in the judgment of the investigator, limits compliance with study requirement, substantially increases risk of incurring AEs or compromises the ability to give written informed consent.
• Current or prior use of immunosuppressive medication within 14 days before the first dose of durvalumab.
• Receipt of live attenuated vaccine within 30 days prior to the first dose of study treatment.
• Any concurrent systemic chemotherapy, immunotherapy, biologic or hormonal therapy for cancer treatment.
• Any unresolved toxicity (Common Terminology Criteria for Adverse Event (CTCAE) grade ≥ 2) caused by previous cancer therapy, excluding alopecia, vitiligo.

• Patients with Grade ≥ 2 neuropathy will be evaluated on a case-by-case basis after consultation with the study physician.
• Patients with irreversible toxicity not reasonably expected to be exacerbated by treatment with olaparib and/or durvalumab may be included only after consultation with the study physician.
• Concomitant use of strong CYP3A inhibitors.The required washout period prior to starting study treatment (olaparib) is 2 weeks.
• Concomitant use of strong CYP3A inducers. The required washout period prior to starting study treatment (olaparib) is 5 weeks for phenobarbital and 3 weeks for other agents.
• Major surgery within 4 weeks prior to the first dose of study treatment. Patients must have recovered from the surgical procedure. Implanted port placement is not considered as a major surgery.
• Known allergy or hypersensitivity to olaparib or durvalumab, or to any excipient.
• Contraindication to MRI or to the contrast medium used for MRI (gadolinium).
• Participation in another clinical study, unless it is an observational (non-interventional) clinical study or during the follow-up period of an interventional study
• Female patients who are pregnant or male or female patients of reproductive potential who are not willing to employ effective birth control from screening to 3 months after the last dose of study treatment.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

AstraZeneca

INDUSTRY

Sponsor Role: collaborator

European Organisation for Research and Treatment of Cancer - EORTC

NETWORK

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Etienne Brain

Role: STUDY_CHAIR

Institut Curie Paris

Other Identifiers

2022-003594-33

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

EORTC-1984-BCG

Identifier Type: -

Identifier Source: org_study_id