Comparison of CSII and MDI in Pediatric Patients With Type 1 Diabetes

NCT ID: NCT05201846

Last Updated: 2022-03-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

66 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-01-18

Study Completion Date

2023-03-31

Brief Summary

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Prospective, randomized, open-label, two-sequence crossover study to investigate the effects of continuous subcutaneous insulin injection (CSII, using DIA:CONN G8 insulin pump) in pediatric patients with type 1 diabetes using multiple daily insulin (MDI) injection

Detailed Description

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This trial consists of two crossover periods of 5 weeks each (MDI to CSII or CSII to MDI), followed by an extended period of 12 weeks (MDI or CSII). Each intervention period has wash-out period (5 days) excluded from the outcome measurements.

Conditions

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Type 1 Diabetes

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Continuous subcutaneous insulin infusion

Continuous subcutaneous insulin infusion using insulin pump (DIA:CONN G8) with continuous glucose monitoring

Group Type EXPERIMENTAL

DIA:CONN G8 insulin pump

Intervention Type DEVICE

Subjects on continuous subcutaneous insulin infusion system with CGM

Multiple daily insulin injection

Multiple daily insulin injection with continuous glucose monitoring

Group Type ACTIVE_COMPARATOR

Multiple daily insulin injection

Intervention Type OTHER

Subjects on multiple daily insulin injection with CGM

Interventions

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DIA:CONN G8 insulin pump

Subjects on continuous subcutaneous insulin infusion system with CGM

Intervention Type DEVICE

Multiple daily insulin injection

Subjects on multiple daily insulin injection with CGM

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

1. The subject is aged 2-17
2. The subject with one or more of the below at diagnosis

* serum c-peptide \< 0.6 ng/mL
* positive glutamic acid decarboxylase (GAD) antibody
* positive Islet cell antibody
* positive anti-Insulin antibody
* positive anti-Islet Antigen-2 (IA-2) antibody
3. The subject was diagnosed with type 1 diabetes ≥ 1 year
4. The subject is treated with multiple daily insulin injection
5. The subject must have available continuous glucose monitoring (CGM) data with a percentage of active CGM time ≥ 70% in the past 4 weeks.

Exclusion Criteria

1. Subjects who were treated with insulin pump therapy within 12 weeks prior to trial
2. Any systemic treatment with drugs known to interfere with glucose metabolism within 12 weeks prior to trial
3. Subjects with underlying hematologic disorders that can affect the HbA1c levels
4. Subjects with underlying medical disorders that can affect glucose metabolism
5. Subjects with a neuropsychiatric disorder such as depression or eating disorder
6. Subjects with underlying thyroid disorders and abnormal thyroid function
Minimum Eligible Age

2 Years

Maximum Eligible Age

17 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Seoul National University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Choong Ho Shin

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Choong Ho Shin, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Seoul National University Hospital

Locations

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Seoul National University Bundang Hospital

Seongnam-si, Gyeonggi-do, South Korea

Site Status NOT_YET_RECRUITING

Seoul National University Hospital

Seoul, , South Korea

Site Status RECRUITING

Countries

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South Korea

Central Contacts

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Young Ah Lee, MD, PhD

Role: CONTACT

82-2-2072-2308

Yun Jeong Lee, MD

Role: CONTACT

82-2-2072-2811

Facility Contacts

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Jae Hyun Kim, MD, PhD

Role: primary

82-31-787-7287

Young Ah Lee, MD, PhD

Role: primary

82-2-2072-2308

Yun Jeong Lee, MD

Role: backup

82-2-2072-2811

Other Identifiers

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21111431275

Identifier Type: -

Identifier Source: org_study_id

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