Pregnolia System Intra-observer Variability

NCT ID: NCT05200117

Last Updated: 2024-03-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

26 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-01-12

Study Completion Date

2023-12-17

Brief Summary

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The Pregnolia System is a CE-marked medical device assessing the mechanical stiffness of cervical tissue in women. The Pregnolia Probe has been engineered to minimize the influence of differences in handling and technique by the user.

This project aims to study intra-observer variability of the Pregnolia System in pregnant women in the clinical setting.

Furthermore, a same day repeated measurement serves to investigate the time period needed to recover the pre-measurement stiffness state due to viscoelasticity of the cervical tissue.

Detailed Description

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Conditions

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Cervix; Pregnancy Cervical Stiffness

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Nulliparous cohort

Cervical stiffness will be measured in the same subject sequentially between days and during the same day and at different gestational ages.

Pregnolia System

Intervention Type DEVICE

The cervical stiffness is measured with the Pregnolia System three times over a two-day period.

Multiparous cohort

Cervical stiffness will be measured in the same subject sequentially between days and during the same day and at different gestational ages.

Pregnolia System

Intervention Type DEVICE

The cervical stiffness is measured with the Pregnolia System three times over a two-day period.

Interventions

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Pregnolia System

The cervical stiffness is measured with the Pregnolia System three times over a two-day period.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Informed Consent signed by the subject
* Pregnant woman
* Singleton pregnancy
* 18 years or older
* Nulliparous cohort: nulliparous pregnant woman
* Multiparous cohort: multiparous pregnant woman

Exclusion Criteria

* Lack of informed consent
* Placenta praevia totalis with haemorrhage (irrespective of severity)
* Severe vaginal bleeding
* Rupture of membranes before 34 weeks (to be excluded with pH test)
* Visible tissue scarring at 12 o'clock position on cervix
* Light bleeding (if the bleeding can be stopped, it is no longer an exclusion criterion)
* Cervical dilation ≥ 3 cm
* Cerclage or pessary in place
Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Pregnolia AG

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Kantonsspital Frauenfeld

Frauenfeld, , Switzerland

Site Status

Countries

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Switzerland

Other Identifiers

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F-405-11 vs 3.0, 2023-07-21

Identifier Type: -

Identifier Source: org_study_id

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