Biomarkers of Atrial Fibrillation Complicated With Stroke Based on Proteomics and Metabolomics

NCT ID: NCT05181787

Last Updated: 2022-01-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Total Enrollment

200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-12-20

Study Completion Date

2023-12-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Thrombus shedding in patients with atrial fibrillation (AF) can lead to cerebral artery embolism. Stroke caused by AF is very dangerous, which not only threatens the life of patients, but also seriously affects the quality of life. This study aims to explore the biomarkers of stroke in patients with AF by integrating proteomics and metabolomics data, and establish the network relationship of stroke in patients with AF, so as to reveal the molecular mechanism of stroke in patients with AF.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Atrial Fibrillation Stroke

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

AF

Patients with AF

Proteomics

Intervention Type DIAGNOSTIC_TEST

Proteomic data were obtained by LC-MS/MS Analysis-DIA platform.

Metabolomics

Intervention Type DIAGNOSTIC_TEST

Metabolomic data were obtained by UPLC-QTOF/MS platform.

AF and stroke

Patients with AF complicated with stroke

Proteomics

Intervention Type DIAGNOSTIC_TEST

Proteomic data were obtained by LC-MS/MS Analysis-DIA platform.

Metabolomics

Intervention Type DIAGNOSTIC_TEST

Metabolomic data were obtained by UPLC-QTOF/MS platform.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Proteomics

Proteomic data were obtained by LC-MS/MS Analysis-DIA platform.

Intervention Type DIAGNOSTIC_TEST

Metabolomics

Metabolomic data were obtained by UPLC-QTOF/MS platform.

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

1. Age 18 years or above
2. Admission with atrial fibrillation or clinic visit for atrial fibrillation
3. Receive routine anticoagulant therapy;
4. Signing the consent form

Exclusion Criteria

1. Pregnant women;
2. Lactating women;
3. Severe mitral stenosis;
4. Severe impairment of liver function;
5. Severe renal insufficiency;
6. Thyroid dysfunction requiring treatment.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Yue LI

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Yue LI

Professor

Responsibility Role SPONSOR_INVESTIGATOR

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Yan

Harbin, Heilongjiang, China

Site Status RECRUITING

Countries

Review the countries where the study has at least one active or historical site.

China

Central Contacts

Reach out to these primary contacts for questions about participation or study logistics.

Haiyu Zhang, MD

Role: CONTACT

86-451-85555009

Facility Contacts

Find local site contact details for specific facilities participating in the trial.

Yan Shi, MD

Role: primary

+8645185555671

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

AF and stroke 1

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

Specific Electrophenotypes in Atrial Fibrillation
NCT05366530 ACTIVE_NOT_RECRUITING
Optimal Ablation Strategies for Persistent AF With HF
NCT07153718 ACTIVE_NOT_RECRUITING NA