Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
12 participants
INTERVENTIONAL
2022-04-14
2023-07-18
Brief Summary
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Detailed Description
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Specific Aim: To examine the effects of acute exercise on the consolidation of therapeutic safety learning. It is hypothesized that participants who engage in 30-min of moderate-intensity aerobic exercise following the first session of imaginal exposure will show larger between-session (visit 2 to 3) reductions in heart rate and anxiety during imaginal exposure to trauma narratives compared to participants who engage in light-intensity exercise.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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Moderate Intensity Exercise
Visit 1: Participants will complete study screening, PTSD assessments, and provide written narrative for a traumatic event and a neutral control event.
Visit 2: Participants will complete eight trials of imaginal exposure (blocks of four neutral and four trauma narrative trials presented as text and sound) with heart rate monitoring and skin conductance. Anxiety will be measured at baseline and after each imagery trial. Participants will then complete 30 minutes of moderate intensity (70-75% maximum heart rate) exercise on a treadmill.
Visit 3: Participants will complete eight more imaginal trials with heart rate and anxiety ratings as per visit 2.
Experimental
Behavioral: Moderate Intensity Exercise The moderate-intensity aerobic exercise session will consist of walking or running at a moderate intensity (i.e., between 70-75% maximum heart rate) for 30 minutes on a treadmill.
Control - Low Intensity Exercise
Visit 1: Participants will complete study screening, PTSD assessments, and provide written narrative for a traumatic event and a neutral control event.
Visit 2: Participants will complete eight trials of imaginal exposure (blocks of four neutral and four trauma narrative trials presented as text and sound) with heart rate monitoring and skin conductance. Anxiety will be measured at baseline and after each imagery trial. Participants will then complete 30 minutes of light intensity (40-50% maximum heart rate) exercise on a treadmill.
Visit 3: Participants will complete eight more imaginal trials with heart rate and anxiety ratings as per visit 2.
Active Control
Behavioral: Low Intensity Exercise Control participants will maintain light-intensity activity (i.e., walking at 40-50% of maximum heart rate) for 30 minutes.
Interventions
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Experimental
Behavioral: Moderate Intensity Exercise The moderate-intensity aerobic exercise session will consist of walking or running at a moderate intensity (i.e., between 70-75% maximum heart rate) for 30 minutes on a treadmill.
Active Control
Behavioral: Low Intensity Exercise Control participants will maintain light-intensity activity (i.e., walking at 40-50% of maximum heart rate) for 30 minutes.
Eligibility Criteria
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Inclusion Criteria
* English speaking
* Medically healthy
Exclusion Criteria
* Major medical disorders (such as cancer, AIDS)
* Psychotic disorders
* Intellectual disabilities
* Developmental disorders
* Active substance use disorders
* Pregnancy or probably pregnancy
* Body mass index greater than or equal to 35
* Daily cannabis use
* History of any cardiac disease
* Inability to provide informed consent
* Physical disabilities that prohibit task performance (such as deafness or blindness)
* Self-reported history of loss of consciousness (greater than 30 minutes)
21 Years
50 Years
ALL
Yes
Sponsors
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Thomas Adams
OTHER
Responsible Party
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Thomas Adams
Assistant Professor
Principal Investigators
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Thomas G Adams Jr, PhD
Role: PRINCIPAL_INVESTIGATOR
University of Kentucky
Locations
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University of Kentucky
Lexington, Kentucky, United States
Countries
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Other Identifiers
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67199
Identifier Type: -
Identifier Source: org_study_id
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