Demonstration of the Medical Interest of the VisioCyt® Artificial Intelligence Test

NCT ID: NCT05176145

Last Updated: 2023-10-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

400 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-04-05

Study Completion Date

2025-05-31

Brief Summary

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European, multicenter clinical trial with VisioCyt®, an in vitro diagnostic medical device. VisioCyt® is an innovative solution for the early diagnosis of bladder cancer.

Detailed Description

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VisioCyt® is based on a patented technology, combining bright-field imaging and artificial intelligence, from a simple urine sample from which the cells are extracted .

The main objective of the study is to demonstrate the medical superiority of the VisioCyt® test versus conventional cytology for detecting recurrence of bladder tumors, in patients monitoring non-muscle infiltrating bladder tumors at high and very high risk of progression

Conditions

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Non-muscle Invasive Bladder Cancer (NMIBC)

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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single arm

Only one arm. The urine collection from each patient will be used for VisioCyt® test and conventional cytology

Group Type OTHER

VisioCyt®

Intervention Type DEVICE

* Cytological and endoscopic examination is planned as part of the usual management of patients under surveillance of Non-muscle invasive bladder cancer (NMIBC), according to the CCAFU guidelines.
* Urine collection for conventional cytology and VisioCyt® test

Interventions

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VisioCyt®

* Cytological and endoscopic examination is planned as part of the usual management of patients under surveillance of Non-muscle invasive bladder cancer (NMIBC), according to the CCAFU guidelines.
* Urine collection for conventional cytology and VisioCyt® test

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Age ≥18 years old and autonomous
* Patient understanding national language well and able to understand the protocol.
* Patient information and informed consent signature before the start of the study
* Patients under surveillance of Non-muscle invasive bladder cancer (NMIBC) at high and very high risk of progression, whatever the stage on the basis of a histological result. The diagnosis (primary or recurrence) should be less than or equal to 24 months (the last histology result confirming a bladder cancer with high or very high risk of recurrence is taken into account).

Exclusion Criteria

* Patients who have had total bladder resection or bladder reconstruction
* Age \<18 years old
* Person deprived of liberty or under guardianship (including curatorship)
* Bladder cancer outside of urothelial carcinoma
* Associated high urinary tract carcinoma
* Kidney transplant patient (BK virus)
* Pelvic radiotherapy patient (prostate cancer)
* Patients with or under surveillance of a muscle-infiltrating bladder tumor
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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FONDATION FORCE POUR L'INNOVATION ET LA RECHERCHE EN SANTE

UNKNOWN

Sponsor Role collaborator

Vitadx

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Hôpital Académique ERASME

Anderlecht, , Belgium

Site Status RECRUITING

CHU Angers

Angers, , France

Site Status RECRUITING

CHU de Caen

Caen, , France

Site Status RECRUITING

CHU de Clermont Ferrand

Clermont-Ferrand, , France

Site Status RECRUITING

CHU Grenoble

Grenoble, , France

Site Status RECRUITING

CHU Nantes

Nantes, , France

Site Status RECRUITING

Hôpital Bichat-Claude Bernard,

Paris, , France

Site Status RECRUITING

Hôpital Pitié-Salpétrière, APHP

Paris, , France

Site Status RECRUITING

Clinique la Croix du Sud

Quint-Fonsegrives, , France

Site Status RECRUITING

CHU de Rennes

Rennes, , France

Site Status RECRUITING

CHU Strasbourg

Strasbourg, , France

Site Status RECRUITING

Hopital Foch

Suresnes, , France

Site Status RECRUITING

CHU Toulouse

Toulouse, , France

Site Status RECRUITING

CHU Tours

Tours, , France

Site Status RECRUITING

Pr Maria Jose Ribal

Barcelona, , Spain

Site Status RECRUITING

Countries

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Belgium France Spain

Central Contacts

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Stéphanie Grojean, PhD

Role: CONTACT

33 (0)383501921

Facility Contacts

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Thierry Roumeguere, Pr

Role: primary

Pierre Bigot

Role: primary

Xavier Tillou, Pr

Role: primary

Laurent Guy, Pr

Role: primary

Clément Sarrazin, Pr

Role: primary

Jérôme Rigaud, Pr

Role: primary

Evanguelos Xylinas, Pr

Role: primary

Rouprêt Morgan, Pr

Role: primary

Benjamin Pradere, Pr

Role: primary

Grégory Verhoest, Dr

Role: primary

Hervé Lang, Pr

Role: primary

Thierry Lebret, Pr

Role: primary

Mathieu Roumiguié, Dr

Role: primary

Franck Bruyère, Pr

Role: primary

Maria Jose Ribal, Pr

Role: primary

Other Identifiers

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DMIA-2021

Identifier Type: -

Identifier Source: org_study_id

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