A Study on the Safety of Ozanimod Exposure in Pregnant Women and Their Offspring

NCT ID: NCT05170126

Last Updated: 2025-11-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

1182 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-07-15

Study Completion Date

2032-06-30

Brief Summary

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The purpose of this study is to provide information on maternal, fetal, and infant outcomes following exposure of ozanimod during pregnancy so that participants and physicians can weigh the benefits and risks of exposure to the pharmaceutical during pregnancy and make informed treatment decisions.

Detailed Description

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Conditions

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Multiple Sclerosis

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Ozanimod-exposed participants

Women with a diagnosis of multiple sclerosis (MS) who are exposed to ozanimod during the exposure window.

No interventions assigned to this group

Comparator-exposed participants

Women with a diagnosis of MS who are not exposed to ozanimod or other sphingosine 1-phosphate (S1P) therapies during the exposure window but who are exposed to other products approved to treat MS during the exposure window.

No interventions assigned to this group

Unexposed participants

Women with a diagnosis of MS who are not exposed to ozanimod or other products approved to treat MS during the exposure window.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Diagnosis of Multiple sclerosis (MS)
* Currently or recently pregnant
* Reside in the United States, Canada or Germany.

Exclusion Criteria

• Exposure to other S1P therapies, cladribine, or mitoxantrone during the first trimester.
Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Bristol-Myers Squibb

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Bristol-Myers Squibb

Role: STUDY_DIRECTOR

Bristol-Myers Squibb

Locations

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Evidera INC.

Bethesda, Maryland, United States

Site Status RECRUITING

Evidera

Bethesda, Maryland, United States

Site Status RECRUITING

Marienhospital Herne, Klinikum Der Ruhr-Universitaet Bochum

Herne, , Germany

Site Status RECRUITING

Countries

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United States Germany

Central Contacts

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BMS Study Connect Contact Center www.BMSStudyConnect.com

Role: CONTACT

855-907-3286

First line of the email MUST contain the NCT# and Site #.

Role: CONTACT

Facility Contacts

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Marielle Bassel, Site 0003

Role: primary

Marielle Bassel, Site 0001

Role: primary

Kerstin Hellwig, Site 0002

Role: primary

+49 (0)234 509-3920

Related Links

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Other Identifiers

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IM047-003

Identifier Type: -

Identifier Source: org_study_id

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