Oral Nutritional Supplementation in Children at Risk of Undernutrition

NCT ID: NCT05161000

Last Updated: 2024-07-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

279 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-04-18

Study Completion Date

2024-06-11

Brief Summary

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The objective of this randomized, controlled trial is to evaluate the effects of consuming a pediatric oral nutritional supplement (ONS) plus dietary counseling for 120 days on anthropometric growth, strength, and nutritional status, compared with dietary counseling alone in undernourished children in the United States.

Detailed Description

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Conditions

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Undernutrition

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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Oral Nutritional Supplement (ONS) Group

Two servings per day in addition to dietary counseling

Group Type EXPERIMENTAL

Oral Nutritional Supplement

Intervention Type OTHER

ONS plus dietary counseling

Dietary counseling

Intervention Type OTHER

dietary counseling

Control Group

dietary counseling

Group Type OTHER

Dietary counseling

Intervention Type OTHER

dietary counseling

Interventions

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Oral Nutritional Supplement

ONS plus dietary counseling

Intervention Type OTHER

Dietary counseling

dietary counseling

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Child is 36 months - 107 months of age.
* Child is undernourished as determined by BMI for age z-score or Mid-upper-arm circumference z-score
* Child's caregiver has voluntarily signed and dated an informed consent form (ICF), approved by an IRB, and provided Health Insurance Portability and Accountability Act (HIPAA) or other applicable privacy regulation authorization prior to any participation in the study.
* Child's caregiver is willing to abstain from providing non-study oral nutrition supplements during the study period duration.
* Child's caregiver is able and willing to follow study procedures and record data in parent diaries and complete any forms or assessments needed during the study.
* Child is willing to consume the study product for the duration of the study, if randomized to intervention group

Exclusion Criteria

* Child has a height-for-age z-score ≥ 0.
* Child is currently drinking an oral nutritional supplement (ONS) on a regular basis (≥ 15 days in the past month)
* Child is participating in another study that has not been approved as a concomitant study by AN.
* Child has been diagnosed with the following:

* Galactosemia, or an allergy or intolerance to any ingredient found in the study product
* Acute or chronic infections including but not restricted to respiratory infections, diarrhea, Hepatitis B or C, HIV infection or tuberculosis
* Severe gastrointestinal disorders such as celiac disease, short bowel syndrome, pancreatic insufficiency, or cystic fibrosis
* Neoplastic, renal, hepatic or cardiovascular, hormonal or metabolic disorders, Down's syndrome or significant, uncorrected cardiac anomalies that may impact growth
* Infantile anorexia nervosa, developmental disability, including physical disorders such as cerebral palsy, or a developmental delay that is considered too severe for participation
* Disorders of hemoglobin structure, function or synthesis
* Clinically significant nutritional deficiency requiring specialty nutritional therapy
* Any other clinically significant medical condition, which in the investigator's opinion, makes him or her unsuitable for inclusion in the study.
Minimum Eligible Age

36 Months

Maximum Eligible Age

107 Months

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Abbott Nutrition

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Jennifer Williams, MPH

Role: STUDY_CHAIR

Abbott Nutrition

Locations

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Midway Medical Clinic

Oneonta, Alabama, United States

Site Status

HealthStar Research Glenwood

Glenwood, Arkansas, United States

Site Status

HealthStar Research, LLC

Hot Springs, Arkansas, United States

Site Status

L.A. Universal Research Center, Inc.

Los Angeles, California, United States

Site Status

Kissimmee Clinical Research

Kissimmee, Florida, United States

Site Status

Dade Research Center, LLC

Miami, Florida, United States

Site Status

D&H National Research Centers

Miami, Florida, United States

Site Status

Suncoast Research, Assoc., LLC

Miami, Florida, United States

Site Status

Springs Medical Research

Owensboro, Kentucky, United States

Site Status

Velocity Clinical Research

Covington, Louisiana, United States

Site Status

Southern Clinical Research

Zachary, Louisiana, United States

Site Status

Alivation Research (Primary Care)

Lincoln, Nebraska, United States

Site Status

Javara Inc. 3380

Winston-Salem, North Carolina, United States

Site Status

Tribe Clinical Research LLC.

Greenville, South Carolina, United States

Site Status

Javara, Inc. 3377

Dallas, Texas, United States

Site Status

Proactive Clinical Research

Edinburg, Texas, United States

Site Status

Gentle Pediatrics

Sugar Land, Texas, United States

Site Status

Countries

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United States

Other Identifiers

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AL48

Identifier Type: -

Identifier Source: org_study_id

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