Assessment of the Response to the Complete Vaccination Guidelines Against Sars-cov2

NCT ID: NCT05153850

Last Updated: 2022-01-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

243 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-01-01

Study Completion Date

2022-09-01

Brief Summary

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Prospective observational single-center study in which the impact of anti-TNF biological treatment on the humoral response after complete vaccination against SARS-COV2 in patients with inflammatory bowel disease is analyzed.

Detailed Description

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Prospective observational single-center study in which the impact of anti-TNF biological treatment on the humoral response after complete vaccination against SARS-COV2 in patients with inflammatory bowel disease is analyzed.

The first objective is to compare the seroconversion rate after full vaccination against SARS-COV2 in patients with IBD treated with anti-TNF drugs versus patients treated with Ustekinumab / Vedolizumab and patients without immunosuppressive treatment.

The Patients included in the study belong to the health area of the Virgen Macarena University Hospital who meet the following inclusion criteria and none for exclusion.

Conditions

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COVID-19

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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Cases

Patients diagnosed with inflammatory bowel disease with the complete vaccination regimen.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Be of legal age (\> 18 years).
* Diagnosis of inflammatory bowel disease (Crohn's Disease or Ulcerative Colitis).
* Complete vaccination schedule (one or two doses depending on previous SARS-Cov2 infection) between one and four months prior to the determination of anti-SARS-Cov2 antibodies.
* Treatment with biological therapy for at least 6 weeks prior to the time of vaccination for the group of patients treated with biological drugs.

Exclusion Criteria

* Last vaccination dose more than four months ago from the determination of antibodies against SARS-Cov2.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Fundación Pública Andaluza para la gestión de la Investigación en Sevilla

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Federico Argüelles Arias

Role: PRINCIPAL_INVESTIGATOR

Hospital Universitario Virgen Macarena

Locations

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Hospital Universitario Virgen Macarena

Seville, Andalusia, Spain

Site Status

Countries

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Spain

Central Contacts

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Federico Argüelles Arias

Role: CONTACT

955 00 80 00

Carlos García Pérez

Role: CONTACT

955 04 31 27

Facility Contacts

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Federico Argüelles Arias

Role: primary

955 00 80 00

Carlos García Pérez

Role: backup

955 04 31 27

Other Identifiers

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FIS-COV-2021-01

Identifier Type: -

Identifier Source: org_study_id

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