ADRCs in The Treatment of Hand Dysfunction Due to Scleroderma

NCT ID: NCT05148598

Last Updated: 2022-09-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

PHASE3

Total Enrollment

174 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-02-28

Study Completion Date

2025-12-30

Brief Summary

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The primary objective of this study is to assess the safety and efficacy of the Celution Device in the processing of an autologous graft consisting of adipose derived regenerative cells (ADRCs) in the treatment of hand dysfunction due to scleroderma.

Detailed Description

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The primary objective of this study is to assess the safety and efficacy of the Celution Device in the processing of an autologous graft consisting of adipose derived regenerative cells (ADRCs) in the treatment of hand dysfunction due to scleroderma.

Conditions

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Scleroderma, Diffuse

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

* Prospective
* Randomized Parallel Group
* Placebo-Controlled
* Safety and Efficacy Trial
Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors
Placebo is visually indistinguishable from active treatment.

Study Groups

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ADRC Arm

Subjects in the ADRC arm will receive standard care and active treatment (ADRCs)

Group Type EXPERIMENTAL

ADRCs

Intervention Type DEVICE

Adipose Derived Regenerative Cells (ADRCs) processed with Celution System

Standard Care

Intervention Type OTHER

Standard care

Standard Care Arm

Subjects in the Standard Care arm will receive standard care and Placebo

Group Type PLACEBO_COMPARATOR

Standard Care

Intervention Type OTHER

Standard care

Placebo

Intervention Type OTHER

Placebo visually indistinguishable from ADRCs

Interventions

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ADRCs

Adipose Derived Regenerative Cells (ADRCs) processed with Celution System

Intervention Type DEVICE

Standard Care

Standard care

Intervention Type OTHER

Placebo

Placebo visually indistinguishable from ADRCs

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Diffuse cutaneous scleroderma (duration \> 5 years)
* Cochin Hand Function Scale ≥ 20 units
* Symptoms consistent with Raynaud's Phenomenon
* Ability to safely undergo liposuction

Exclusion Criteria

* Active infection
* Contracture(s) of any finger
* Sympathectomy within 6 months of Screening Visit
* Rheumatoid Arthritis
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Paracrine, INC.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Other Identifiers

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STAR-II, 2021-03.V1

Identifier Type: -

Identifier Source: org_study_id

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