Assessment of Platelet Storage Lesion(PSL)in Platelet Concentrates
NCT ID: NCT05144074
Last Updated: 2021-12-03
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
180 participants
OBSERVATIONAL
2021-12-01
2025-03-31
Brief Summary
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Detailed Description
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Platelets play an integral role in hemostasis by its response to vascular injury. The relevance of platelet component therapy was better understood in the 1950s and 1960s when severe and fatal hemorrhagic complications of chemotherapy in leukemia were studied
The collected blood units were randomly assigned to two groups:
1. Non-filtered platelet concentrates (NF-PC group).
2. leukocyte-depleted platelet concentrates (LD-PC group). P-selectin (CD62p) is a type of glycoprotein stored in the Weibel-Palade bodies of vascular endothelial cells and platelet α-granules. Activated CD62P is a transmembrane protein expressed on the platelet surface. During platelet activation, the expression of CD62P on the surface of the cell membrane is dramatically increased in PCs without leukocyte depletion, due to the presence of WBCs and cytokines ,and is accompanied by an increase in the expression level of plasma soluble CD62
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Non-filtered platelet concentrates (NF-PC group).
In NF-PC group, 90 whole blood units were collected with Tripple blood bags, Six NF-PCs were pooled together and stored in a horizonal shaker at 20 ± 2C for 5 days .
No interventions assigned to this group
leukocyte-depleted platelet concentrates (LD-PC group).
In LD-PC group, another 90 whole blood units were collected using Whole Blood Filter Saving Platelets (WB-SP) bags with an integrated leukoreduction filter
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Donors who had not taken any antiplatelet drugs for two weeks prior to donation
* pre-collection platelet count ≥200×109 /L.
* Blood grouping.
* Serological assays for all blood donors (HBsAgs, HCV antibodies, HIV Ag/Ab Syphilis antibodies) on Architect i 2000 SR or Centaur XPT (chemoluminescence).
Exclusion Criteria
* Donors who had taken any antiplatelet drugs for two weeks prior to donation
* pre-collection platelet count \<200×109 /L.
* Reactive serology
18 Years
60 Years
ALL
No
Sponsors
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Assiut University
OTHER
Responsible Party
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Merna Mamdoh Ayad Benyamen
resident
Central Contacts
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References
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Freireich EJ. Origins of platelet transfusion therapy. Transfus Med Rev. 2011 Jul;25(3):252-6. doi: 10.1016/j.tmrv.2011.01.003. Epub 2011 Mar 2.
Kaushansky K. The molecular mechanisms that control thrombopoiesis. J Clin Invest. 2005 Dec;115(12):3339-47. doi: 10.1172/JCI26674.
Solves Alcaina P. Platelet Transfusion: And Update on Challenges and Outcomes. J Blood Med. 2020 Jan 24;11:19-26. doi: 10.2147/JBM.S234374. eCollection 2020.
Cines DB, Levine LD. Thrombocytopenia in pregnancy. Hematology Am Soc Hematol Educ Program. 2017 Dec 8;2017(1):144-151. doi: 10.1182/asheducation-2017.1.144.
Other Identifiers
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platelet storage lesion
Identifier Type: -
Identifier Source: org_study_id