DEXAMETHASONE for Non-urgent Thoracic Surgery

NCT ID: NCT05136781

Last Updated: 2023-04-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

1600 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-11-16

Study Completion Date

2024-03-31

Brief Summary

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Thoracic surgery is at high risk of respiratory complications. Despite the improvement of surgical procedures such as video-thoracoscopy, respiratory complications appear in 15 to -20% of procedures. Thoracic surgery induces local pulmonary inflammation which is involved in the occurrence of post-operative respiratory failure. Similarly to the example of the acute respiratory distress syndrome, corticosteroids could reduce lung injury secondary to immunological stress. In addition, recent studies suggest that dexamethasone could lead to a reduction of respiratory complications after major non cardiothoracic surgery.

Since dexamethasone is recommended to prevent postoperative nausea and vomiting, around one in two patients receive dexamethasone during anesthetic induction. By retrospective analysis with compensation of bias by propensity score, the investigators aim to assess the effect of dexamethasone to prevent respiratory complications

Detailed Description

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Conditions

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Thoracic Surgery Anesthesiology Corticosteroids Respiratory Complication

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

RETROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* age : minimum 18 years old
* Patients who underwent scheduled lung resection surgery

Exclusion Criteria

* absence of patient's consent
* age under 18 years
* pregnant women
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Centre Hospitalier Universitaire, Amiens

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Centre Hospitalier Universitaire d'Amiens

Amiens, Picardie, France

Site Status RECRUITING

Countries

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France

Central Contacts

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YOHAN GERMAIN, MD

Role: CONTACT

0322037347

Facility Contacts

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YOHAN GERMAIN, MD

Role: primary

0322037347

Other Identifiers

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PI2021_843_0202

Identifier Type: -

Identifier Source: org_study_id

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