Trial Outcomes & Findings for Noradrenergic Activity and Attention (NCT NCT05120713)

NCT ID: NCT05120713

Last Updated: 2024-09-19

Results Overview

The oculomotor suppression effect is a lower likelihood that salient display items will be the target of the initial eye movement in a visual search task compared to nonsalient display items. This effect is calculated from the percentage of first saccades toward a non-target stimuli subtracted by the percentage of first saccades toward the distractor stimuli. Greater % of first saccades toward the target would demonstrate better goal-directed attentional control and greater % of first saccades toward the distractor would demonstrate increased distractibility. Thus, a greater oculomotor suppression effect would demonstrate an increased ability to inhibit salient information that is irrelevant to the task.

• Recruitment status: COMPLETED
• Target enrollment: 140 participants
• Primary outcome timeframe: Calculated once at the end of the 1 day experiment
• Results posted on: 2024-09-19

Participant Flow

Participant milestones

Measure	Young Adults Young Adults aged 18-30	Older Adults Older Adults aged 50-80
Overall Study STARTED	70	70
Overall Study COMPLETED	70	70
Overall Study NOT COMPLETED	0	0

Reasons for withdrawal

Withdrawal data not reported

Baseline Characteristics

Noradrenergic Activity and Attention

Baseline characteristics by cohort

Measure	Young Adults n=70 Participants Young Adults aged 18-30	Older Adults n=70 Participants Older Adults aged 50-80	Total n=140 Participants Total of all reporting groups
Age, Customized Age · 18 to 30 years old inclusive	70 Participants n=5 Participants	0 Participants n=7 Participants	70 Participants n=5 Participants
Age, Customized Age · 50 to 80 years old inclusive	0 Participants n=5 Participants	70 Participants n=7 Participants	70 Participants n=5 Participants
Sex/Gender, Customized Sex · Male	21 Participants n=5 Participants	20 Participants n=7 Participants	41 Participants n=5 Participants
Sex/Gender, Customized Sex · Female	48 Participants n=5 Participants	50 Participants n=7 Participants	98 Participants n=5 Participants
Sex/Gender, Customized Sex · Choose not to report	1 Participants n=5 Participants	0 Participants n=7 Participants	1 Participants n=5 Participants
Race (NIH/OMB) American Indian or Alaska Native	0 Participants n=5 Participants	0 Participants n=7 Participants	0 Participants n=5 Participants
Race (NIH/OMB) Asian	31 Participants n=5 Participants	10 Participants n=7 Participants	41 Participants n=5 Participants
Race (NIH/OMB) Native Hawaiian or Other Pacific Islander	0 Participants n=5 Participants	0 Participants n=7 Participants	0 Participants n=5 Participants
Race (NIH/OMB) Black or African American	4 Participants n=5 Participants	7 Participants n=7 Participants	11 Participants n=5 Participants
Race (NIH/OMB) White	15 Participants n=5 Participants	47 Participants n=7 Participants	62 Participants n=5 Participants
Race (NIH/OMB) More than one race	10 Participants n=5 Participants	4 Participants n=7 Participants	14 Participants n=5 Participants
Race (NIH/OMB) Unknown or Not Reported	10 Participants n=5 Participants	2 Participants n=7 Participants	12 Participants n=5 Participants
Region of Enrollment United States	70 participants n=5 Participants	70 participants n=7 Participants	140 participants n=5 Participants

PRIMARY outcome

Timeframe: Calculated once at the end of the 1 day experiment

Population: Both young and older adults completed the experiment at baseline and under increased arousal (order counterbalanced).

The oculomotor suppression effect is a lower likelihood that salient display items will be the target of the initial eye movement in a visual search task compared to nonsalient display items. This effect is calculated from the percentage of first saccades toward a non-target stimuli subtracted by the percentage of first saccades toward the distractor stimuli. Greater % of first saccades toward the target would demonstrate better goal-directed attentional control and greater % of first saccades toward the distractor would demonstrate increased distractibility. Thus, a greater oculomotor suppression effect would demonstrate an increased ability to inhibit salient information that is irrelevant to the task.

Outcome measures

Measure	Young Adults Baseline n=70 Participants Young adults aged 18-30 under no intervention	Older Adults Basline n=70 Participants Older adults aged 50-80 under no intervention	Young Adults + Arousal n=70 Participants Young adults aged 18-30 years older during the threat of shock block	Older Adults + Arousal n=70 Participants Older adults aged 50-80 years older during the threat of shock block
Initial Eye-movements Toward Target and Distractor Shapes Measured by an Eye-tracker	3.8 percentage of first saccades Standard Error 0.3	4.4 percentage of first saccades Standard Error 1.2	3.6 percentage of first saccades Standard Error 0.7	4.5 percentage of first saccades Standard Error 1.2

Adverse Events

Young Adults

Serious events: 0 serious events

Other events: 0 other events

Deaths: 0 deaths

Older Adults

Serious events: 0 serious events

Other events: 0 other events

Deaths: 0 deaths

Serious adverse events

Adverse event data not reported

Other adverse events

Adverse event data not reported

Additional Information

Dr. Andy Kim

University of Southern California

Phone: 213-740-5156

Email: andyk@usc.edu

Results disclosure agreements

• Principal investigator is a sponsor employee
• Publication restrictions are in place