Microbiology and Treatment Outcome of Acute Exacerbation of Bronchiectasis in Hong Kong

NCT ID: NCT05112055

Last Updated: 2024-04-03

Basic Information

• Recruitment Status: RECRUITING
• Total Enrollment: 200 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2021-12-02
• Study Completion Date: 2025-12-01

Brief Summary

Bronchiectasis is a common disease worldwide with a high burden on healthcare resources. In Hong Kong (HK), local microbiological and clinical data regarding acute exacerbation of bronchiectasis (AEB) is lacking, in particular the frequency of pseudomonas aeruginosa (PA) in AEB is yet to be elucidated. A better understanding of the microbiology of AEB will provide evidence for judicious use of appropriate antibiotics in patients hospitalized for AEB to facilitate treatment and discharge.

This study aims to

1. elucidate the microbiology of AEB using both traditional culture and newer molecular multiplex methods,

2. identify factors associated with PA infection, and

3. describe the management and treatment outcome of AEB in HK

Detailed Description

Bronchiectasis is a common disease worldwide with a high burden on healthcare resources. In Hong Kong (HK), bronchiectasis ranked 5th highest as a cause of respiratory mortality, was the 6th highest reason for respiratory inpatient bed-days and was the 7th highest cause of respiratory hospitalization in Hong Kong in 2005.

Local microbiological and clinical data regarding acute exacerbation of bronchiectasis (AEB) is lacking, in particular the frequency of pseudomonas aeruginosa (PA) in AEB is yet to be elucidated. Traditional respiratory specimen takes time and lack sensitivity, a newer multiplex molecular method may be beneficial in improving sensitivity and reducing turnover time to detect pathogens involved in AEB. A better understanding of the microbiology of AEB will provide evidence for judicious use of appropriate antibiotics in patients hospitalized for AEB to facilitate treatment and discharge.

This study aims to

1. elucidate the microbiology of AEB using both traditional culture and newer molecular multiplex methods,

2. identify factors associated with PA infection, and

3. describe the management and treatment outcome of AEB in HK

Conditions

Bronchiectasis

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Eligibility Criteria

Inclusion Criteria

1. Patients admitted to participating hospital with a clinical diagnosis of acute exacerbation of bronchiectasis (AEB), defined as a change in bronchiectasis treatment associated with deterioration in three or more of the following key symptoms for at least 48 hours: cough; sputum volume and/or consistency; sputum purulence; breathlessness and/or exercise tolerance; fatigue and/or malaise; or haemoptysis.

2. Patients with an established diagnosis of bronchiectasis, defined as the presence of cough, shortness of breath, chronic sputum production, recurrent respiratory infection, or a combination thereof with CT thorax scan confirmation of the presence of bronchiectasis indicated by a bronchoarterial ratio of > 1, lack of tapering, airway visibility within 1 cm of the pleural surface, or a combination thereof.

Exclusion Criteria

1. Patients unable to provide informed consent

2. Age < 18 years

3. Pregnancy

4. Bronchiectasis due to known cystic fibrosis

5. Bronchiectasis is not the main or co-dominant respiratory disease

6. Traction bronchiectasis due to interstitial lung disease

7. Prior lung transplantation for bronchiectasis

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Pamela Youde Nethersole Eastern Hospital

OTHER

Sponsor Role: lead

Responsible Party

Wong Charles

Resident Specialist

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Charles Wong

Role: PRINCIPAL_INVESTIGATOR

Pamela Youde Nethersole Eastern Hospital

Locations

Charles Wong

Hong Kong, Other, Hong Kong

Site Status: RECRUITING

Countries

Hong Kong

Central Contacts

Charles Wong

Role: CONTACT

wc679@ha.org.hk

25956111

Facility Contacts

Charles Wong

Role: primary

wc679@ha.org.hk

25956111

Other Identifiers

Pro_AEB_2021

Identifier Type: -

Identifier Source: org_study_id