Real-world Evaluation of Prevalence of Ocular Adverse Events in Patients With Neovascular (Wet) Agerelated Macular Degeneration (AMD) Who Received Anti-VEGF Agents (IRIS Registry)
NCT ID: NCT05110209
Last Updated: 2021-12-21
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
331541 participants
OBSERVATIONAL
2020-07-15
2020-11-20
Brief Summary
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Detailed Description
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IRIS Registry data from 01/01/2019 to 12/31/2019 for patients with a diagnosis of wet AMD who were treated with ≥1 anti-VEGF agent (excluding brolucizumab) were included.
* Identification period: Patients fulfilling the selection criteria during the period from 01/01/2019 to 12/31/2019 were identified
* Index date: 01/01/2019
* Study Period: 01/01/2019 to 12/31/2019
* Pre-index period: 01/01/2018 to 12/31/2018
* Post-index period: 01/01/2019 to 12/31/2019
Conditions
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Study Design
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COHORT
RETROSPECTIVE
Study Groups
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Aflibercept
Patients/patient eyes who were treated only with aflibercept in 2019
Aflibercept
intravitreal injection
Ranibizumab
Patients/patient eyes who were treated only with ranibizumab in 2019
Ranibizumab
intravitreal injection
Bevacizumab
Patients/patient eyes who were treated only with bevacizumab in 2019
Bevacizumab
intravitreal injection
≥2 Different Anti- VEFGFs
Patients/patient eyes who were treated with ≥2 different anti-VEGFs in 2019
No interventions assigned to this group
Interventions
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Aflibercept
intravitreal injection
Ranibizumab
intravitreal injection
Bevacizumab
intravitreal injection
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* ≥1 Healthcare Common Procedure Coding System (HCPCS) code (J code) or National Drug Code (NDC) code for treatment with an anti-VEGF agent (excluding brolucizumab) in 2019
* ≥18 years old in 2019
* ≥2 wet AMD-related office visits in 2019
Exclusion Criteria
* Patient eyes that did not have laterality any time during 2018-2019
* Treatment with brolucizumab during 2019
18 Years
85 Years
ALL
No
Sponsors
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Novartis Pharmaceuticals
INDUSTRY
Responsible Party
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Principal Investigators
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Novartis Pharmaceuticals
Role: STUDY_DIRECTOR
Novartis Pharmaceuticals
Locations
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Novartis Investigative Site
East Hanover, New Jersey, United States
Countries
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Related Links
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Results for CRTH258AUS20 from the Novartis Clinical Trials Website
Other Identifiers
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CRTH258AUS20
Identifier Type: -
Identifier Source: org_study_id