Microlyte in Prevention of SSI After Open Ventral Hernia Repair
NCT ID: NCT05093894
Last Updated: 2022-10-10
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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WITHDRAWN
NA
INTERVENTIONAL
2021-12-14
2022-10-06
Brief Summary
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The purpose of this study is to find out if placing Microlyte (which is a dissolvable sheet coated in silver) on the surgical incision is better than placing nothing on the surgical incision when it comes to decreasing the chance of surgical site infections.
The study device has been cleared by the Food and Drug Administration (FDA) for use on surgical incisions.
A total of 280 participants will be included in the study.
Participation will last for about 90 days.
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Detailed Description
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Those who agree to participate in the study will undergo the following:
Information will be collected, including demographics, past medical and surgical history, and hospital outcomes.
On the day of surgery, participants will be "randomized" into one of the study groups listed below.
* Group 1: The study device will be cut into strips and placed in the surgical incision
* Group 2: Nothing will be placed in the surgical incision
For both groups, the surgical incision will then be closed with absorbable sutures, which is the usual treatment.
Participants will be seen by the study doctor 30 and 90 days after surgery for a checkup. At the 30-day visit, participants will have a physical examination, and the study doctor will check to see if any complications have happened since the last visit. The 90-day follow-up visit can be done in person or over the telephone and will be done to check and see if there have been any problems with the healing of the surgical incision.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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Group 1: Microlyte will be cut into strips and placed on the surgical incision
Microlyte will be cut into strips and placed on the surgical incision
Group 1
Microlyte will be cut into strips and placed on the subcutaneous space
Group 2: Nothing will be placed on the surgical incision
Nothing will be placed on the surgical incision
No interventions assigned to this group
Interventions
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Group 1
Microlyte will be cut into strips and placed on the subcutaneous space
Eligibility Criteria
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Inclusion Criteria
* Patients undergoing open hernia repair with retromuscular or preperitoneal placement of polypropylene mesh in clean (Class I) operative fields, and who are candidates for complete skin closure
* Capable and willing to attend the scheduled postoperative visits
* Signed ICF for study enrollment
Exclusion Criteria
* Minimally invasive repairs (laparoscopy, robotics)
* CDC Wound Class II-IV
* Irrigation of the wound or peritoneal cavity with antibiotic or antimicrobial fluid
* Inability to completely close the midline fascia
* Mesh placed as a bridge, onlay, or intraperitoneal position to the fascia
* Skin left open or packed at the time of the index operation
* Use of wound wicks at the time of the index operation
* Use of an investigational product within the preceding 60 days
* Allergy to silver
18 Years
ALL
No
Sponsors
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Wake Forest University Health Sciences
OTHER
Kendall Healthcare Group, Ltd.
INDUSTRY
Prisma Health-Upstate
OTHER
Responsible Party
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Principal Investigators
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Alfredo M Carbonell, DO
Role: PRINCIPAL_INVESTIGATOR
Prisma Health
Locations
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Mission Hospital/HCA Healthcare
Asheville, North Carolina, United States
Carolinas Medical Center/Atrium Health
Charlotte, North Carolina, United States
Prisma Health
Greenville, South Carolina, United States
Countries
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Other Identifiers
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Pro00115720
Identifier Type: -
Identifier Source: org_study_id
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