Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
20 participants
INTERVENTIONAL
2021-10-30
2026-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
SINGLE_GROUP
BASIC_SCIENCE
NONE
Study Groups
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CYP2C19*2 and CYP2C19*3 Variants
The group of participants has been genotyped to have the CYP2C19\*2 and/or CYP2C19\*3 variant during the first part of the study. The participants will consume 1 oz water mixed with 500mg limonene (Jarrow Formula orange peel extract) and be asked to swish 5 times and swallow. All participants will then provide breath samples over the course of 2 hours. The breath sample outcomes will be compared to those of the wild-type CYP2C19 study subjects.
Limonene
The investigators will ask the participants to swish 5 times and swallow 1 oz water mixed with 500mg limonene (Jarrow Formula orange peel extract). The participant will be monitored for a total of 2 hours. Breath samples will be acquired at a total of 11 time points throughout the study. Measurements include 2 baseline measurements followed by the orange peel extract consumption.
Wildtype CYP2C19
The group of participants has been genotyped to have wild-type CYP2C19. The participants will consume 1 oz water mixed with 500mg limonene (Jarrow Formula orange peel extract) and be asked to swish 5 times and swallow. All participants will then provide breath samples over the course of 2 hours. The breath sample outcomes will be compared to those of the CYP2C19\*2 and/or CYP2C19\*3 study subjects.
Limonene
The investigators will ask the participants to swish 5 times and swallow 1 oz water mixed with 500mg limonene (Jarrow Formula orange peel extract). The participant will be monitored for a total of 2 hours. Breath samples will be acquired at a total of 11 time points throughout the study. Measurements include 2 baseline measurements followed by the orange peel extract consumption.
Interventions
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Limonene
The investigators will ask the participants to swish 5 times and swallow 1 oz water mixed with 500mg limonene (Jarrow Formula orange peel extract). The participant will be monitored for a total of 2 hours. Breath samples will be acquired at a total of 11 time points throughout the study. Measurements include 2 baseline measurements followed by the orange peel extract consumption.
Eligibility Criteria
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Inclusion Criteria
* Gender: Male or Female
* Ethnicities: East Asian
Exclusion Criteria
* previous allergic reaction to limonene, citrus fruits, bovine gelatin, glycerin
* past medical history of cerebrovascular or cardiovascular disease
* veganism
* history of chest pain or shortness of breath in the past month
* certain medications that are CYP2C19 substrates or CYP2C19 inhibitors
* Non-East Asian descent
* age less than 18 y.o or age greater than 45 y.o
18 Years
45 Years
ALL
Yes
Sponsors
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Stanford University
OTHER
Responsible Party
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Eric Gross
Assistant Professor
Locations
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Stanford School of Medicine
Stanford, California, United States
Countries
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Central Contacts
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Facility Contacts
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Eric Gross, MD/PhD
Role: primary
Other Identifiers
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59978
Identifier Type: -
Identifier Source: org_study_id