The Effects of Low Dose Naltrexone (LDN) on Diseases of Aging

NCT ID: NCT05307627

Last Updated: 2024-08-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

WITHDRAWN

Study Classification

OBSERVATIONAL

Study Start Date

2022-03-14

Study Completion Date

2023-12-14

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This retrospective, observational study will assess the health status of short- and long-term low-dose naltrexone (LDN) users.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Long-term (\>5 years), intermediate-term (1-5 years), and short-term low-dose naltrexone (LDN) users (\<12 months) will be contacted for a retrospective, observational assessment of their health status. Participants will be asked to complete a series of questionnaires assessing their quality of life, general physical and mental health, family history, the occurrence of age-related diseases, and immune status. Additionally, blood tests for immune and longevity markers will be optional for a subset of participants.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Aging

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Long-term (>5 years) LDN users

Participants who have been using LDN for over 5 years

low-dose naltrexone

Intervention Type DRUG

LDN doses \<20 mg/day

intermediate-term (1-5 years) LDN users

Participants who have been using LDN for at least 1 year, but shorter than 5 years.

low-dose naltrexone

Intervention Type DRUG

LDN doses \<20 mg/day

short-term (<12 months) LDN users

Participants who have been using LDN for less than a year. This group will serve as the control group.

low-dose naltrexone

Intervention Type DRUG

LDN doses \<20 mg/day

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

low-dose naltrexone

LDN doses \<20 mg/day

Intervention Type DRUG

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

LDN

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Adults (aged 18-120)
* Any sex
* Any ethnicity
* Taking LDN
* Willing to complete health questionnaires
* Technologically competent to complete web forms
* Subgroup: willing to undergo blood testing

Exclusion Criteria

* LDN doses over 20 mg/day
* Terminal cancer patients (defined as stage IV and/or with a life expectancy of 12 months or less)
Minimum Eligible Age

18 Years

Maximum Eligible Age

120 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

AgelessRx

INDUSTRY

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Sajad Zalzala, MD

Role: PRINCIPAL_INVESTIGATOR

AgelessRx

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

AgelessRx

Ann Arbor, Michigan, United States

Site Status

Countries

Review the countries where the study has at least one active or historical site.

United States

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

ALRx002

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

Pharmacokinetics of SP-104
NCT05002946 COMPLETED PHASE1
Effects of Naproxen on Physical Performance
NCT00410995 TERMINATED PHASE4
The Effect of Losartan on Cephalexin
NCT07300670 NOT_YET_RECRUITING PHASE1