Multicenter Retrospective Observatory of Patients With Acute Myeloid Leukemia to Core Binding Factor
NCT ID: NCT05070208
Last Updated: 2025-10-02
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
400 participants
OBSERVATIONAL
2021-09-22
2024-05-05
Brief Summary
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The results of this treatment regimen need to be evaluated. Known prognostic factors such as signaling mutations, clonal interference or residual disease follow-up (MRD) will be analyzed and updated in this recent cohort. The interaction between residual disease and mutational profile will be evaluated on the prognosis. Treatment with gemtuzumab-ozogamycin and first-line allogeneic transplantation will be investigated, depending on prognostic factors including associated mutations and residual disease. The course and early treatment of molecular relapses will be analyzed. The treatment and prognosis of cytological relapses will be described with in particular the role of tyrosine kinase inhibitors and therapeutic intensification.
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Detailed Description
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Conditions
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Study Design
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COHORT
RETROSPECTIVE
Interventions
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NOT PROVIDED
NOT PROVIDED
Eligibility Criteria
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Inclusion Criteria
* Diagnosis of acute myeloid leukemia with CBF confirmed by cytogenetics (karyotype and / or FISH): t (8; 21), inv (16) or t (16; 16) and / or molecular biology (RUNX1-RUNX1T1 fusions or CBFB-MYH11)
* Initial management by intensive chemotherapy, hypomethylants or targeted therapies
Exclusion Criteria
18 Years
ALL
No
Sponsors
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Acute Leukemia French Association
OTHER
Responsible Party
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Principal Investigators
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ITZYKSON Raphael, Dr
Role: PRINCIPAL_INVESTIGATOR
SAINT LOUIS PARIS
Locations
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Chu Amiens
Amiens, , France
Centre Hospitalier Victor Dupouy
Argenteuil, , France
AP-HP-GHU - Hôpital AVICENNE
Bobigny, , France
CHU de la cote de Nacre
Caen, , France
CH Métropole Savoie
Chambéry, , France
Hôpital MILITAIRE PERCY
Clamart, , France
Centre hospitalier Sud Francilien
Corbeil-Essonnes, , France
Henri Mondor Aphp
Créteil, , France
Dijon Chu
Dijon, , France
Centre Hospitalier de Dunkerque
Dunkirk, , France
Centre Hospitalier de Versailles André Mignot
Le Chesnay, , France
LENS CHR
Lens, , France
CHU
Lille, , France
Limoges Chu
Limoges, , France
CHU La Conception
Marseille, , France
Centre Antoine Lacassagne
Nice, , France
CHU Nice,Hopital Archet 1
Nice, , France
Hopital Pitié-Salpétrière APHP
Paris, , France
Hôpital Necker - APHP
Paris, , France
Hôpital Saint Louis- APHP
Paris, , France
Saint Antoine
Paris, , France
Centre Hospitalier Lyon Sud
Pierre-Bénite, , France
Centre Hospitalier René Dubos
Pontoise, , France
Centre Hospitalier de Roubaix
Roubaix, , France
Centre Hospitalier de St Quentin
Saint-Quentin, , France
Institut Gustave Roussy
Villejuif, , France
Countries
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Other Identifiers
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RETRO-CBF
Identifier Type: -
Identifier Source: org_study_id
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