Auvergne-Rhône-Alpes-Limousin Research Database for Still's Diseases in Children and Adults
NCT ID: NCT05055882
Last Updated: 2024-04-26
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
400 participants
OBSERVATIONAL
2020-02-01
2025-12-31
Brief Summary
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Classically, three evolutionary profiles of Adult-Onset Still's disease are individualized, depending on the evolution of symptoms over time:
* a monocyclic systemic form (30% of cases) characterized by clear systemic symptoms and in the foreground compared to the articular signs. This form evolves over several weeks to several months (on average 9 months), without exceeding a year. By definition, there is no recurrence;
* a polycyclic systemic form (30% of cases) defined by the occurrence of at least two systemic or joint episodes, separated by clinical remission intervals greater than two months, or even several years. The symptoms of relapses are not always the same as the initial symptoms. The number and severity of relapses is unpredictable and varies widely from patient to patient, but symptoms tend to become less severe over time.
* a chronic form, with predominant joint involvement (40%), resembling seronegative rheumatoid arthritis. Systemic signs are present during the first outbreaks of the disease. Subsequently, rheumatoid arthritis evolves on its own and one can see joint destruction or conversely ankylosing developments such as the classic bilateral, non-erosive fusing carpitis.
There are reasons to believe that the evolving profile of patients has changed since the emergence and generalization of biotherapies. Furthermore, no prognostic factor for the progression of Adult-Onset Still's disease has been found so far. The differences between pediatric and adult forms need to be confirmed and becoming pediatric forms in adulthood is poorly described.
The objective of this study is to set up a regional research database (Auvergne-Rhône-Alpes-Limousin) in order to describe the characteristics, treatment and evolution of patients with Still's disease.
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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children and adult diagnosed with Still's disease in Auvergne-Rhône-Alpes-Limousin hospital
children and adult with Still's disease in Auvergne-Rhône-Alpes-Limousin hospital
children and adult with Still's disease in Auvergne-Rhône-Alpes-Limousin hospital
Comparison of Adult-Onset Still's disease phenotypes
Interventions
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children and adult with Still's disease in Auvergne-Rhône-Alpes-Limousin hospital
Comparison of Adult-Onset Still's disease phenotypes
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
3 Years
ALL
No
Sponsors
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Hospices Civils de Lyon
OTHER
Responsible Party
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Locations
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Hôpital de la Croix Rousse
Lyon, Auvergne-Rhône-Alpes, France
Centre Hospitalier de Valence
Valence, Drome, France
Centre Hospitalier d'Annecy
Annecy, , France
Centre Hospitalier de Bourg en Bresse
Bourg-en-Bresse, , France
Centre Hospitalier Bourgoin Jallieu
Bourgoin, , France
Centre Hospitalier de Chambéry
Chambéry, , France
Centre Hospitalier de Châlon sur Saône
Châlon Sur Saône, , France
Centre Hospitalier Alpes-Léman (CHAL)
Contamine-sur-Arve, , France
Centre Hospitalier du puy en velay
Le Puy-en-Velay, , France
Centre Hospitalier de Limoges
Limoges, , France
Hopital Saint Luc Saint Joseph
Lyon, , France
Hospices Civils de Lyon - Edouard Herriot
Lyon, , France
Centre Hospitalier de Montélimar
Montélimar, , France
Centre Hospitalier Vienne
Vienne, , France
Centre Hospitalier de Villefranche
Villefranche-sur-Saône, , France
Médipôle de Villeurbanne
Villeurbanne, , France
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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CRC_GHN_2021_003
Identifier Type: -
Identifier Source: org_study_id
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