Angiotensin II Pathway and Postoperative Hypoxemia

NCT ID: NCT05055570

Last Updated: 2024-01-26

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

88 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-08-12

Study Completion Date

2022-06-01

Brief Summary

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Acute type A aortic dissection is often accompanied by postoperative hypoxemia, the cause of which is not fully understood. Angiotensin II is an important component of the renin-angiotensin system (RAS), which has been suggested to be involved in the development of aortic dissection and pulmonary inflammation.The purpose of this study was to investigate the role and mechanism of angiotensin II pathway in postoperative hypoxemia after acute type A aortic dissection, and to provide reference for clinical application

Detailed Description

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Conditions

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Aortic Dissection

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Hypoxemia group

oxygenation index (OI)≤200

No intervention

Intervention Type OTHER

No intervention

Non-hypoxemia group

oxygenation index (OI)\>200

No intervention

Intervention Type OTHER

No intervention

Interventions

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No intervention

No intervention

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* patients undergoing surgery for acute type A aortic dissection
* age between 18 to 80

Exclusion Criteria

* perioperative severe cardiac insufficiency
* rejection of consent
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Beijing Anzhen Hospital

OTHER

Sponsor Role lead

Responsible Party

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Jun Ma

The chief of department of anesthesiology

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Anzhen hospital, Beijing

Beijing, Beijing Municipality, China

Site Status

Countries

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China

References

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Wang X, Ma J, Lin D, Dong X, Wu J, Bai Y, Zhang D, Gao J. The risk factors of postoperative hypoxemia in patients with Stanford type A acute aortic dissection. Medicine (Baltimore). 2023 Aug 18;102(33):e34704. doi: 10.1097/MD.0000000000034704.

Reference Type DERIVED
PMID: 37603505 (View on PubMed)

Provided Documents

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Document Type: Study Protocol and Statistical Analysis Plan

View Document

Other Identifiers

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2021107X

Identifier Type: -

Identifier Source: org_study_id

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