ImmuneSense COVID-19 Variant Study

NCT ID: NCT05054088

Last Updated: 2022-12-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

203 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-10-12

Study Completion Date

2022-07-28

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This study will assess the clinical performance of the T-Detect™ COVID test to identify an immune response to SARS-CoV-2 infection in the setting of multiple circulating variants of the SARS-CoV-2 virus. Performance may vary depending on the variants circulating at the time of testing, including newly emerging strains of SARS-CoV-2 and their prevalence, which changes over time.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Covid19

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Cohort 1

Subjects who have tested positive for SARS-CoV-2 by EUA RT-PCR testing with symptoms compatible with SARS-CoV-2 infection.

T-Detect COVID test

Intervention Type DEVICE

• The T-DetectTM COVID test is an EUA granted investigational device that is indicated to assess a T-cell immune response to SARS-CoV-2 via the testing of blood samples from patients with signs and symptoms of suspected COVID-19.

Cohort 2

Subjects who have tested positive for SARS-CoV-2 by EUA RT-PCR testing with symptoms compatible with SARS-CoV-2 infection.

T-Detect COVID test

Intervention Type DEVICE

• The T-DetectTM COVID test is an EUA granted investigational device that is indicated to assess a T-cell immune response to SARS-CoV-2 via the testing of blood samples from patients with signs and symptoms of suspected COVID-19.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

T-Detect COVID test

• The T-DetectTM COVID test is an EUA granted investigational device that is indicated to assess a T-cell immune response to SARS-CoV-2 via the testing of blood samples from patients with signs and symptoms of suspected COVID-19.

Intervention Type DEVICE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

Participants must satisfy the following criteria to be enrolled in the study:

i. Individuals who have tested positive for SARS-CoV-2 via EUA RT-PCR testing. ii. Male and female participants of any race and ethnicity between 18 to 89 years of age (inclusive) at the time of enrollment in the study. iii. Must be able to communicate with the investigator, understand, and comply with the requirements of the study. iv. Must be able to provide estimated date of symptom onset. v. Must be available for specimen collection greater than 14 days (i.e., 15 days inclusive onward) and less than 107 days (i.e., 106 days inclusive or less) after first exhibiting symptoms of confirmed SARS-CoV-2 infection.

Exclusion Criteria

The presence of any of the following will exclude a participant from enrollment:

* Individuals who did not test positive for SARS-CoV-2 on EUA RT-PCR.
* Protected populations including pregnant women, prisoners, mentally disabled persons, and wards-of-the state.
* Any significant condition, laboratory abnormality, or psychiatric illness that would prevent the participant from safely participating in the study.
* Exposure to a SARS-CoV-2 investigational drug (new chemical entity) within 60 days prior to enrollment at the discretion of the Sponsor.
* Receipt of immunosuppressive medications, such as, but not limited to, recent moderate- or high-dose systemic steroids or immunomodulators within 1 month prior to enrollment at the discretion of the Sponsor.
* Treatment with immunosuppressants/ immunomodulators that do not impact T cells or B cells may be allowed at the discretion of the Sponsor.
* Steroid formulations including low-dose oral steroids (≤ 10 mg prednisone equivalents per day), inhaled steroids, or topical steroids are not considered exclusionary. Doses \>10 and \<20 mg prednisone equivalents per day, must receive Sponsor approval.
Minimum Eligible Age

18 Years

Maximum Eligible Age

89 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Adaptive Biotechnologies

INDUSTRY

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Darcy Gill, PhD

Role: PRINCIPAL_INVESTIGATOR

Adaptive Biotechnologies

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Decentralized Trial Model- Phoenix

Phoenix, Arizona, United States

Site Status

Decentralized Trial Model- Fullerton

Fullerton, California, United States

Site Status

Decentralized Trial Model- California

Los Angeles, California, United States

Site Status

Decentralized Trial Model- Modesto

Modesto, California, United States

Site Status

Decentralized Trial Model- Sacramento

Sacramento, California, United States

Site Status

Decentralized Trial Model- California

San Diego, California, United States

Site Status

Decentralized Trial Model- San Francisco

San Francisco, California, United States

Site Status

Decentralized Trial Model- Denver

Denver, Colorado, United States

Site Status

Decentralized Trial Model - Washington D.C.

Washington D.C., District of Columbia, United States

Site Status

Decentralized Trial Model- Florida

Miami, Florida, United States

Site Status

Decentralized Clinical Trial Model- New York City

New York, New York, United States

Site Status

Decentralized Trial Model- Portland

Portland, Oregon, United States

Site Status

Decentralized Trial Model- Utah

Salt Lake City, Utah, United States

Site Status

Decentralized Trial Model- Seattle

Seattle, Washington, United States

Site Status

Decentralized Trial Model- Vancouver, WA

Vancouver, Washington, United States

Site Status

Countries

Review the countries where the study has at least one active or historical site.

United States

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

PRO-00974

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

Innovation in Tuberculosis
NCT04002869 UNKNOWN