Clinicopathologic and Ancillary Testing of Primary Clear Cell Carcinoma of the Cervix

NCT ID: NCT05046080

Last Updated: 2025-08-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

70 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-08-06

Study Completion Date

2026-09-29

Brief Summary

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This study aims to provide a comprehensive report on clinicopathologic features, immunohistochemical/biomarker testing and molecular profile of cervical clear cell carcinoma. This study may help researchers learn more about the molecular profile of cervical clear cell carcinoma.

Detailed Description

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PRIMARY OBJECTIVE:

I. To perform a retrospective clinicopathologic study on patients diagnosed and treated for clear cell carcinoma of the cervix at M D Anderson Cancer Center (MDACC) and to delineate the immunohistochemical and molecular profile of these cases.

OUTLINE:

Patients' medical records are reviewed retrospectively, and archival tumor tissue analyzed by immunohistochemistry and next generation sequencing.

Conditions

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Human Papillomavirus-Independent Cervical Adenocarcinoma, Clear Cell-Type

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

RETROSPECTIVE

Study Groups

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Observational (medical record review)

Patients' medical records are reviewed retrospectively, and archival tumor tissue analyzed by immunohistochemistry and next generation sequencing.

Electronic Health Record Review

Intervention Type OTHER

Medical records reviewed

Laboratory Biomarker Analysis

Intervention Type OTHER

Correlative studies

Interventions

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Electronic Health Record Review

Medical records reviewed

Intervention Type OTHER

Laboratory Biomarker Analysis

Correlative studies

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Patients diagnosed with clear cell carcinoma of the cervix at MDACC
Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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M.D. Anderson Cancer Center

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Anasis Malpica

Role: PRINCIPAL_INVESTIGATOR

M.D. Anderson Cancer Center

Locations

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M D Anderson Cancer Center

Houston, Texas, United States

Site Status RECRUITING

Countries

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United States

Facility Contacts

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Anasis Malpica

Role: primary

713-792-4655

Related Links

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http://www.mdanderson.org

M D Anderson Cancer Center

Other Identifiers

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NCI-2021-08814

Identifier Type: REGISTRY

Identifier Source: secondary_id

2020-0989

Identifier Type: OTHER

Identifier Source: secondary_id

2020-0989

Identifier Type: -

Identifier Source: org_study_id

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