Study of Antenatal and Postnatal Data of Anorectal Malformations Diagnosed at Montpellier University Hospital Over a 10-year Period (2010-2020)
NCT ID: NCT05045560
Last Updated: 2021-09-21
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
98 participants
OBSERVATIONAL
2010-01-01
2021-08-30
Brief Summary
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Anorectal malformations (ARMs) are part of a spectrum of malformations due to an abnormal separation between the urogenital and digestive tracts during embryonic life. The prevalence of ARM is 1/2000 - 1/5000 live births, making it a relatively common malformation.
The impact of an ARM depends mainly on the type of malformation, which can be difficult to evaluate in the antenatal period, and whether it is isolated or associated (50-80%) with other malformations or genetic syndromes. Only 1 to 16% of ARMs are diagnosed in the antenatal period.
The objective of this study is to compare cases of prenatal diagnosis of ARM, cases of postnatal diagnosis of ARM with other antenatal ultrasound abnormalities, and those with normal antenatal ultrasound, in terms of management and functional prognosis, to identify ways to improve prenatal counseling.
Materials and methods :
In this retrospective monocentric study, the investigators have included all fetuses and newborns born between January 2010 and September 2020 with anorectal malformations, diagnosed from postnatal radiological examinations and surgical or autopsy reports at the University Hospital of Montpellier. The Krickenbeck classification was used to classify the ARMs and to assess the functional prognosis.
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Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
RETROSPECTIVE
Study Groups
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antenatal diagnosis of anorectal malformation
Groupe 1 : antenatal diagnosis of anorectal malformation
No interventions assigned to this group
postnatal diagnosis of anorectal malfiormation with associated anomalies on antenatal ultrasound
Groupe 2 : postnatal diagnosis of anorectal malfiormation with associated anomalies on antenatal ultrasound
No interventions assigned to this group
postnatal diagnosis of anorectal malformation with anormal antenatal ultrasound
Groupe 3 : postnatal diagnosis of anorectal malformation with anormal antenatal ultrasound
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* diagnosed from postnatal radiological examinations and surgical or autopsy reports at the University Hospital of Montpellier.
Exclusion Criteria
* anorectal malformation associated with an abdominal wall defect
ALL
No
Sponsors
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University Hospital, Montpellier
OTHER
Responsible Party
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Principal Investigators
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Florent Fuchs, MD; PHD
Role: STUDY_DIRECTOR
University Hospital, Montpellier
Locations
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Uhmontpellier
Montpellier, , France
Countries
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Other Identifiers
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RECHMPL20_0616
Identifier Type: -
Identifier Source: org_study_id
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