Near-infrared Autofluorescence (NIRAF)-Guided Total Thyroidectomy: Impact in Low-volume, Non-parathyroid Institutions

NCT ID: NCT05043584

Last Updated: 2024-01-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

78 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-09-15

Study Completion Date

2023-12-01

Brief Summary

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Hypoparathyroidism is the most frequent complication in total thyroidectomy. The use of near-infrared autofluorescence (NIRAF) intraoperatively, seems to reduce the rate of transient hypoparathyroidism. Unfortunately, no effect on permanent hypoparathyroidism has been shown.

In order to cover every aspect of the impact of NIRAF in thyroid surgery, an evaluation in low-volume, non-parathyroid institutions is needed. This is the overall aim of our current studies. The objective of this specific study is to evaluate the impact of NIRAF on immediate, transient and permanent hypoparathyroidism following total thyroidectomy in low-volume, non-parathyroid institutions.

Detailed Description

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Patients referred for total thyroidectomy will undergo NIRAF-assisted surgery (Fluobeam LX) at two low-volume ENT-departments with no experience in parathyroid surgery.

PTH and ionized calcium will be assessed preoperatively, on postoperative day 1 (POD1) and minimum two months following surgery. Patients who still fulfill the criteria for hypoparathyroidism at that point will be followed until one year following surgery. The rates of immediate, transient and permanent hypoparathyroidism will be assessed and compared to a historic cohort.

Conditions

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Autofluorescence Thyroidectomy Hypoparathyroidism Hypocalcemia

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Prospective cohort study
Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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(A): NIRAF-assisted surgery

Patients undergoing NIRAF-assisted total thyroidectomy

Group Type EXPERIMENTAL

Fluobeam LX, Fluoptics, Grenoble, France

Intervention Type DEVICE

See arm description

Interventions

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Fluobeam LX, Fluoptics, Grenoble, France

See arm description

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Patients referred for total thyroidectomy
* Age \> 18
* Able to understand patient information
* Able to give informed consent

Exclusion Criteria

* Previous thyroid surgery
* Need for accelerated surgery
* Insufficient biochemical profile
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Esbjerg Hospital - University Hospital of Southern Denmark

OTHER

Sponsor Role collaborator

Regional Hospital West Jutland

OTHER

Sponsor Role lead

Responsible Party

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Ali Abood

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Department of Otorhinolaryngology, Hospital South West Jutland

Esbjerg, , Denmark

Site Status

Department of Otorhinolaryngology, Regional Hospital West Jutland

Holstebro, , Denmark

Site Status

Countries

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Denmark

Other Identifiers

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Autofluorescence1.0

Identifier Type: -

Identifier Source: org_study_id

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