Effect of Early Systemic Stabilization Therapy on Recent Onset Vitiligo

NCT ID: NCT05037981

Last Updated: 2021-09-08

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 25 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2015-10-10
• Study Completion Date: 2021-08-20

Brief Summary

Vitiligo is a distressing disorder of depigmentation. In spite of multiple successful therapeutic regimens, disease relapse remains a challenge to patients and physicians. Most guidelines consider systemic treatments only in rapidly progressive disease with wider surface areas. This delay in halting the immune attack, may give the chance for further disease progression as well as establishment of resident memory T cell population predisposing to future disease relapses. The aim of this study was to assess the ability of early systemic therapy of localized (<2% BSA), recent onset (<6 months) vitiligo to control disease activity and minimize the possibility of recurrence.

Conditions

Vitiligo

Study Design

• Observational Model Type: CASE_ONLY
• Study Time Perspective: PROSPECTIVE

Eligibility Criteria

Inclusion Criteria

• Patients ≥ 6 years old of both genders
• Early onset vitiligo (˂6m duration)
• Body surface area (BSA) affected ≤2%

Exclusion Criteria

• Patients who received any previous treatment for vitiligo
• Pregnant and lactating females
• Patients with other cutaneous or systemic autoimmune diseases
• Patients with contraindication to systemic corticosteroids

• Minimum Eligible Age: 6 Years
• Maximum Eligible Age: 60 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Cairo University

OTHER

Sponsor Role: lead

Responsible Party

Dina Saadi

Dr

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Samia Esmat, MD

Role: PRINCIPAL_INVESTIGATOR

Cairo University

Rania Mogawer, MD

Role: PRINCIPAL_INVESTIGATOR

Cairo University

Dalia Bassiony, MD

Role: STUDY_DIRECTOR

Cairo University

Suzan Shalaby, MD

Role: STUDY_CHAIR

Cairo University

Rehab Hegazy, MD

Role: STUDY_CHAIR

Cairo University

Nanis Ragab, MD

Role: STUDY_CHAIR

Cairo University

Sarah Ibrahim

Role: STUDY_CHAIR

Cairo University

Other Identifiers

vit105

Identifier Type: -

Identifier Source: org_study_id