Intensive Dose Tinzaparin in Hospitalized COVID-19 Patients

NCT ID: NCT05036824

Last Updated: 2021-09-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

300 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-10-01

Study Completion Date

2022-04-30

Brief Summary

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The primary objective of this study is to evaluate the current management approach with "intermediate" or "therapeutic" doses of tinzaparin for thromboprophylaxis in hospitalized patients, non on ICU organ support, with confirmed COVID-19.

Detailed Description

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A prothrombotic state, attributable to a cytokine storm induced by severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) and leading to activation of the coagulation cascade, is a recognized feature of Coronavirus disease 2019 (COVID-19) infection. This can manifest in venous thromboembolism (VTE), arterial thrombosis events (ATE), and disseminated intravenous coagulation (DIC) and coagulopathy are reflective of more severe disease and adverse prognosis. A significant number of patients with COVID-19 require single or multiple organ support on the Intensive Care Unit (ICU), estimated to be between 12 and 17% of patients. with the reported mortality in these cohorts between 25 and 40%.

International guidelines recommend that hospitalized patients with COVID-19 should receive pharmacological prophylaxis against VTE, in the absence of contraindications. With respect to how VTE prophylaxis is achieved, Low Molecular Weight Heparins (LMWH), in addition to their well-known anticoagulant properties, appear to have additional antiviral and anti-inflammatory effects that may be potentially beneficial in hospitalized COVID-19 patients.

Though international and national guidelines state that all hospitalized patients with COVID-19 should receive pharmacologic thromboprophylaxis, the rising incidence of thrombotic complications in COVID-19 patients has led a lot of hospitals to adopt the strategy of increasing the dose of anticoagulation for prophylaxis to 'intermediate' or "therapeutic" doses using a risk-adapted strategy with increased doses administration based on factors associated with increased risk; clinicians weigh the benefits and risks of therapeutic anticoagulation in terms of thrombosis and major bleeding risk for individual patients.

Additionally, LMWHs have different physicochemical characteristics as a result of the diverse methods of their manufacturing. The variations in molecular composition and pharmacological properties of LMWHs are reflected in differences in their clinical efficacy and safety. Each LMWH should, therefore, be considered as a unique substance. Tinzaparin is the only LMWH known that is prepared by enzymatic hydrolysis with heparinase. Due to its preparation method, tinzaparin has distinct properties than other LMWHs including and not limited to: higher Anti-IIa activity and Anti-Xa/Anti-IIa activity ratio, the higher release of Tissue Factor Pathway Inhibitor (TFPI), less dependence from renal function for its clearance, and more complete neutralization from its antidote, if needed. Due to the key role of increased Thrombin generation (IIa) and Tissue factor (TF) pathway activation in COVID-19-associated thrombosis , special properties of tinzaparin in Anti-IIa activity and TFPI production and release from endothelial cells, as well as significant effects of TFPI in various vascular, inflammatory, cardiovascular, hematological and oncological disorders, tinzaparin could have an expanded role beyond its well-known anticoagulant function.

The purpose of this study is to evaluate the overall clinical effectiveness and safety of 'intermediate' or "therapeutic" doses of anticoagulation with tinzaparin administered for thromboprophylaxis in COVID-19 patients with moderate disease severity during hospitalization in Greek hospitals.

Conditions

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Covid19 Hospitalization

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

RETROSPECTIVE

Study Groups

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COVID-19 patients

Patients admitted to hospital with COVID-19, PCR+ SARS-CoV-2 infection administered thromboprophylaxis with tinzaparin.

Dosage: intermediate or therapeutic dose Frequency of tinzaparin administration: once daily Duration: Unknown

tinzaparin

Intervention Type DRUG

Daily tinzaparin administration: 8000 - 14000 Anti-Xa IU

Interventions

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tinzaparin

Daily tinzaparin administration: 8000 - 14000 Anti-Xa IU

Intervention Type DRUG

Other Intervention Names

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Innohep

Eligibility Criteria

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Inclusion Criteria

1. Patients admitted to hospital with COVID-19, PCR+ SARS-CoV-2 infection (from any specimen) administered thromboprophylaxis with tinzaparin in intermediate or therapeutic dose
2. Age ≥ 18 years
3. Signed informed consent

Exclusion Criteria

1. Patients admitted to ICU with COVID-19, PCR+ SARS-CoV-2 infection (from any specimen)
2. Age \< 18 years
3. Pregnancy
4. Current diagnosis or suspicion of pulmonary thromboembolism or deep vein thrombosis
5. Progression to death was imminent and inevitable within 24 hours from the admission, irrespective of the provision of treatments
6. Not signed informed consent
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Hospital of Patras

OTHER

Sponsor Role lead

Responsible Party

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K.Akinosoglou MD,PhD

Study Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Karolina Akinosoglou, MD,PhD

Role: PRINCIPAL_INVESTIGATOR

University Hospital of Patras

Locations

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University Hospital of Patras

Pátrai, Achaia, Greece

Site Status RECRUITING

Evangelismos General Hospital

Athens, Attica, Greece

Site Status RECRUITING

General Hopital Elpis

Athens, Attica, Greece

Site Status RECRUITING

University General Hospital of Ioannina

Ioannina, Epirus, Greece

Site Status RECRUITING

General Hospital of Kerkira "Ag. Irini"

Corfu, Ionian Islands, Greece

Site Status RECRUITING

General Hospital of Kozani "Mamatsio"

Kozani, Macedonia, Greece

Site Status RECRUITING

Genereal Hospital of Patras "Ag. Andreas"

Patras, Peloponnese, Greece

Site Status RECRUITING

Countries

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Greece

Central Contacts

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Karolina Akinosoglou, MD,PhD

Role: CONTACT

+306977762897

Facility Contacts

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Karolina Akinosoglou, Ass. Prof.

Role: primary

+30 2610997254

George Marakomichelakis, M.D. Ph.D.

Role: primary

Spyridon Savvanis, M.D. Ph.D

Role: primary

Haralampos ] Milionis, Ass. Prof.

Role: primary

Ilias Papanicolaou, M.D. Ph.D.

Role: primary

Efthalia Randou, M.D. Ph.D.

Role: primary

George Efremidis, M.D. Ph.D.

Role: primary

References

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Provided Documents

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Document Type: Study Protocol and Statistical Analysis Plan

View Document

Other Identifiers

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18634/23-7-2021 pend. aprooval

Identifier Type: -

Identifier Source: org_study_id

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