Real-World Effectiveness of Regorafenib in the Treatment of Patients With Hepatocellular Carcinoma

NCT ID: NCT05024539

Last Updated: 2022-04-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

300 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-06-20

Study Completion Date

2022-12-21

Brief Summary

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Real-World Effectiveness of Regorafenib in the Treatment of Patients With Hepatocellular Carcinoma

Detailed Description

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To analyze the real-world usage pattern, effectiveness and factors associated with the effectiveness of regorafenib in the treatment of patients with Hepatocellular Carcinoma. This retrospective, observational study included clinicopathological and follow-up data of patients with Hepatocellular Carcinoma who were treated with regorafenib from June 2017 to September 2020. Patients with incomplete data were excluded. Overall survival (OS) stratified by combination therapy with programmed cell death ligand-1 (PD-L1) inhibitors, chemotherapy and regorafenib dose was calculated by Kaplan Meier method and log rank test. R software version 4.0 was used for the analysis.

Conditions

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Hepatocellular Carcinoma

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Regorafenib group

Patients were given only regorafenib orally

nonintervention

Intervention Type OTHER

Joint group

The patient was treated with regorafenib orally and in combination with other medications

nonintervention

Intervention Type OTHER

Interventions

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nonintervention

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

1. Must be a pathologically proven Hepatocellular Carcinoma
2. Must have been treated with regorafenib
3. Regorafenib must be used after two lines of standard antitumor therapy

Exclusion Criteria

1. Application is less than one course of treatment with regorafenib
2. First - or second-line treatment with regorafenib
3. Patients with multiple primary cancers
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Henan Cancer Hospital

OTHER_GOV

Sponsor Role collaborator

Shujun Yang

OTHER_GOV

Sponsor Role lead

Responsible Party

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Shujun Yang

Director

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Shujun Yang

Role: STUDY_DIRECTOR

Henan Cancer Hospital

Locations

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Henan cancer hosiptal

Zhengzhou, Henan, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Shujun Yang, bachelor

Role: CONTACT

13803869419

Facility Contacts

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Shujun Yang, bachelor

Role: primary

Other Identifiers

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YShujun2

Identifier Type: -

Identifier Source: org_study_id

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