Surgical Site Infections at a West Cameroon Hospital

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

148 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-04-26

Study Completion Date

2022-02-04

Brief Summary

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Surgical site infections (SSI) constitute an important health concern in low and middle income countries, leading to prolonged hospital stay and increased costs. Previous studies indicate that in Africa up to 1/3 of patients undergoing surgery may be affected by a postoperative infection. The development and implementation of context-specific SSI prevention guidelines is important to reduce this complication. To deploy efficient context-specific measures, data on epidemiology and microbiology of these infections are needed. This means to adapt the prevention measures to the context-specific risk factors for surgical site infections in resource-limited settings, and to give locally adapted recommendations on antimicrobial therapy based on local resistance patterns. However, data in this respect are scarce in low and middle income countries. This present study will contribute to the needed epidemiology and microbiology data on SSI in Cameroon. It will be carried out as a prospective cohort study at the Mbouo Protestant hospital in the West Region of Cameroon. The incidence, microbial spectrum and respective antimicrobial resistance of SSI as well as the risk factors of SSI will be systematically investigated. The study will include 300 patients at the Hôpital Protestant de Mbouo (HPM) who underwent surgery and gave their informed consent for inclusion, the timeframe is 04/2021 - 11/2021. An active SSI surveillance system will be put in place for 30 postoperative days to diagnose SSI.

Expected outcomes:

The incidence of SSI is likely to be higher than 10%. Concerning risk factors, preoperative bodywashing and perioperative antibioprophylaxis is expected to be protective against SSI. Up to 1/3 of SSI are expected to occur after hospital discharge. For the microbial spectrum, a high proportion of Staphylococcus aureus is likely to be found. For the antimicrobial resistance no estimation can be give as data is non-existent in that region from the literature.

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Detailed Description

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Conditions

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Surgical Wound Infection

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Patients without SSI

Patients who underwent surgery and who developed a surgical site infection (SSI) during 30 days after surgery

No interventions assigned to this group

Patients with SSI

Patients who underwent surgery and who didn't develop a surgical site infection (SSI) during 30 days after surgery

Observation of surgical site infections

Intervention Type PROCEDURE

No intervention is done, only observation of routine clinical practice

Interventions

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Observation of surgical site infections

No intervention is done, only observation of routine clinical practice

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Patient underwent surgery at the hospital during study period

Exclusion Criteria

* Unconscious patients, mentally ill patients

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Responsible Party

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Christian Doll

Dr. med. Christian Doll

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Christian Doll, Dr

Role: PRINCIPAL_INVESTIGATOR

Université Evangélique du Cameroun, Cameroon; Hôpital Protestant de Mbouo, Cameroon; Charité University Medical Centre Berlin, Germany; University Medical Centre Jena, Germany