Low Protein Diet in CKD Patients at Risk of Malnutrition

NCT ID: NCT05015647

Last Updated: 2021-08-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

35 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-09-26

Study Completion Date

2020-06-12

Brief Summary

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It's a pilot study with an open label randomized-controlled design. Estimated number of patients should have been 38, taking in account of a maximal drop out up to 20% of the sample. We enrolled 35 patients, 27 of whom terminated the study as per protocol (14 in the Low protein (LP) group and 13 in the Normo Protein (NP) group).

Patients were treated for six months with two different dietary prescriptions:

1. LP group (n=17) was prescribed high calories/low proteins diet (30 Kcal/kg and 0.6-0.7gr/kg respectively). In order to assure prescribed calorie intake, this group was supplemented with commercial protein free products (protein content \<2%).
2. NP group (n=18) was prescribed high calories/normal proteins diet (30 kcal/kg and 0.8 gr/kg respectively).

The primary hypothesis of the study was that in CKD patients at risk of malnutrition (4 ≤ MIS ≥7) with a persistent spontaneous low protein and calories intake, the prescription of a LP diet was not inferior to NP diet regarding the development of malnutrition (i.e.MIS ≥ 8).

We also wanted to test whether in these patients, the prescription of a LP diet was superior to the NP comparator regarding the control of the metabolic complication of chronic kidney diseases (i.e hyperphosphatemia, inflammation and metabolic acidosis), the progression on dyna/sarcopenia, inflammation and possibly on the progression of renal disease itself.

Detailed Description

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Nutritional status will be evaluated through:

* Malnutrition Inflammation Score (MIS),
* Anthropometric measurements,
* albumin, prealbumin, transferrin,
* 24h urinary nitrogen,
* bioimpedance analysis (BIA),
* periodic 24h dietary diaries,
* International Society of Renal Nutrition and Metabolism (ISRNM),

Physical performance will be evaluated through:

* Short Physical Performance Battery (SPPB)
* Handgrip strength

Inflammation assessment:

* c-reactive protein (CRP)
* Interleukine-6 (IL6)
* whole blood Neutrophil/lymphocyte ratio

Renal function assessment:

* eGFR based on serum creatinine and cystatin C
* average creatinine and urea clearance

Uremic metabolic alteration:

* serum urea
* serum phosphate
* serum FGF23
* parathormone (PTH),
* plasma pH and bicarbonate

Time points of evaluation Dietary compliance has been assessed by a trained nutritionist at months 1, 2, 3 and 6. Dietary consumption was estimated by using dietary diaries and normalized catabolic protein rate (nPCR) measurement at baseline, 3 and at 6 months.

Nutritional status and physical performance have been evaluated monthly for the first three months and then at 6 months.

Conditions

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Chronic Kidney Diseases Malnutrition

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Participants were treated for six months with two different dietary prescriptions:

1. LP group (n=17) was prescribed high calories/low proteins diet (30 Kcal/kg and 0.6-0.7gr/kg respectively). In order to assure prescribed calorie intake, this group was supplemented with commercial protein free products (protein content \<2%).
2. NP group (n=18) was prescribed high calories/normal proteins diet (30 kcal/kg and 0.8 gr/kg respectively).
Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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LP group

LP group (n=17) was prescribed high calories/low proteins diet (30 Kcal/kg and 0.6-0.7gr/kg respectively) supplemented with commercial protein free products (protein content \<2%).

Group Type EXPERIMENTAL

LP group

Intervention Type DIETARY_SUPPLEMENT

LP group patients replaced pasta, bread, biscuits etc. with low protein substitutes. We allowed them to consume more animal products than NP, preferring white meat to red meat and trying to limit cold cuts as much as possible. Furthermore, they were advised to prefer fresh or frozen fish, instead of dried or smoked one as well as to prefer fresh cheeses to seasoned ones. As for legumes, we advised to combine them with bread or normal cereals, for protein complementarity.

NP group

NP group (n=18) was prescribed high calories/normal proteins diet (30 kcal/kg and 0.8 gr/kg respectively)

Group Type ACTIVE_COMPARATOR

NP group

Intervention Type OTHER

NP group was given the indication to try to eat the second dish only once a day or to split the portion of the second plate between lunch and dinner, if they wanted to keep the habit of making the meal complete. It was also given the indication to prefer, among protein sources, those of plant origin. We also indicated to alternate or replace cow's milk with plant substitutes such as: rice, almonds' or oats' drinks. Furthermore, we suggested to prefer white meat and to avoid offal and processed meat. Moreover, we indicated to substitute dried or smoked fish with fresh or frozen one.

Interventions

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LP group

LP group patients replaced pasta, bread, biscuits etc. with low protein substitutes. We allowed them to consume more animal products than NP, preferring white meat to red meat and trying to limit cold cuts as much as possible. Furthermore, they were advised to prefer fresh or frozen fish, instead of dried or smoked one as well as to prefer fresh cheeses to seasoned ones. As for legumes, we advised to combine them with bread or normal cereals, for protein complementarity.

Intervention Type DIETARY_SUPPLEMENT

NP group

NP group was given the indication to try to eat the second dish only once a day or to split the portion of the second plate between lunch and dinner, if they wanted to keep the habit of making the meal complete. It was also given the indication to prefer, among protein sources, those of plant origin. We also indicated to alternate or replace cow's milk with plant substitutes such as: rice, almonds' or oats' drinks. Furthermore, we suggested to prefer white meat and to avoid offal and processed meat. Moreover, we indicated to substitute dried or smoked fish with fresh or frozen one.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* advanced CKD not yet on renal replacement therapy (10\< - eGFRcreat \<30 ml/min)
* age \>65 years
* at risk of malnutrition at Malnutrition Inflammation Score (4≤MIS≤7)
* spontaneous low protein-energy intake (proteins \< 0.8g/kg and energy \< 25 kcal/kg).

Exclusion Criteria

* Active chronic infectious diseases
* Heart failure of severity \> NYHA2
* Active neoplastic diseases
* Inability to cooperate
* Presumed overall life expectancy \< 6 month
* Decompensated liver diseases
* Malabsorption
* Decompensated thyroid o surrenal diseases
* Refusal to participate
* Immunosuppressive and/or steroid therapy
Minimum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Simone Vettoretti, Dr

Role: PRINCIPAL_INVESTIGATOR

Fondazione IRCCS Ca'Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy

Locations

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Unit of nephrology, dialysis and renal transplantation - Fondazione IRCCS Ca'Granda Ospedale Maggiore Policlinico di Milano

Milan, , Italy

Site Status

Countries

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Italy

References

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Reference Type DERIVED
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Other Identifiers

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1274/2018

Identifier Type: -

Identifier Source: org_study_id

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