Thiol-disulfide Homeostasis in Patients With Ovarian Cancer

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

115 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-04-09

Study Completion Date

2022-05-01

Brief Summary

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Ovarian cancer is the third most common after endometrial and cervical cancer in societies with a high standard of living; It is the second most common type of gynecological cancer after cervical cancer in societies with a low standard of living, and it is also the deadliest among gynecological cancers. Dynamic thiol-disulfide homeostasis is an antioxidant system that minimizes oxidative damage and prevents cell damage. In the presence of oxidative stress, the thiol groups combine to form the disulfide structure, and when the oxidative stress condition is over, they are separated into thiol groups again. This homeostasis is impaired in conditions that cause oxidative processes such as diabetes, cardiovascular diseases, cancers, rheumatoid arthritis, and chronic kidney failure. This can be determined by measuring the total thiol and native thiol levels. Likewise, the level of ischemia modified albumin increases in the case of oxidative stress. There are studies on this homeostasis in the literature on many types of cancer; There are studies on endometrial cancer and cervical cancer, which are gynecological cancers In this study, the usability of these tests together with other diagnostic tests in the diagnosis of ovarian cancer will be evaluated.

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Detailed Description

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Conditions

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Ovarian Cancer

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Ovarian cancer

The patients with ovarian cancer

No interventions assigned to this group

Control group

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Histopathological diagnosis of ovarian cancer

Exclusion Criteria

* Having an acute or chronic disease that will cause oxidative stress
* Using alcohol/cigarettes/drugs
* Using antioxidant agents (such as vitamins A, C, E)

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes