Effect of Pyridoxine on Behavioral Adverse Events of Levetiracetam

NCT ID: NCT05008354

Last Updated: 2022-03-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-10-01

Study Completion Date

2021-09-01

Brief Summary

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This study is a two-arm parallel group randomized double-blind placebo-controlled trial with the aim of Investigating pyridoxine effect on behavioral side effects of levetiracetam in adult patients with epilepsy.

Detailed Description

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Conditions

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Epilepsy Pyridoxine Behavior Problem

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Pyridoxine

Group Type ACTIVE_COMPARATOR

Pyridoxine

Intervention Type DRUG

Pyridoxine tablet 40mg once daily

Placebo

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Placebo tablet once daily

Interventions

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Pyridoxine

Pyridoxine tablet 40mg once daily

Intervention Type DRUG

Placebo

Placebo tablet once daily

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Age≄18 years
* Patients with epilepsy
* Patients who are treated by levetiracetam (Levebel, Cobel darou) in recent month
* Complaint of behavioral problem
* Patient's consent for participation

Exclusion Criteria

* History of known psychiatric disease
* Pregnancy
* Incidence of psychotic side effects including hallucination, psychosis, suicidal idea or attempt
* Treatment with psychiatric medications
* Alcohol or drug abuse
* Mental retardation to the degree that intervenes comprehension and response to questionnaire
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Mazandaran University of Medical Sciences

OTHER

Sponsor Role collaborator

Nasim Tabrizi

OTHER

Sponsor Role lead

Responsible Party

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Nasim Tabrizi

Associate professor of neurology

Responsibility Role SPONSOR_INVESTIGATOR

Locations

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Bu Ali Sina Hospital

Sari, Mazandaran, Iran

Site Status

Countries

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Iran

Other Identifiers

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5238

Identifier Type: -

Identifier Source: org_study_id

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