Lung Screening in People Cured of Hodgkin Lymphoma

NCT ID: NCT04986189

Last Updated: 2024-11-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

102 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-08-01

Study Completion Date

2024-08-31

Brief Summary

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A single site non-commercial study in which people treated for Hodgkin lymphoma survivors will be invited to have a single low dose CT of thorax for lung cancer screening

Detailed Description

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Conditions

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Hodgkin Lymphoma Lung Cancer

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

SCREENING

Blinding Strategy

NONE

Study Groups

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Invitation to have a low dose CT thorax

All participants are invited to undergo a low dose CT thorax

Group Type OTHER

Low dose CT thorax

Intervention Type DIAGNOSTIC_TEST

A low dose CT scan of the thorax to screen for lung cancer

Interventions

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Low dose CT thorax

A low dose CT scan of the thorax to screen for lung cancer

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Aged 18-80
* 5 year or more survivor of HL
* Any of: a) treated with radiotherapy for HL with radiation dose to the lung b) an alkylating agent containing chemotherapy regimen known to increase lung cancer risk
* Living within approximately 40 miles of The Christie Hospital

Exclusion Criteria

* Previous diagnoses of malignant neoplasm of trachea, bronchus, lung, thymus or pleura
* A current diagnosis of metastatic cancer
* Residents in nursing homes or housebound
* Had a CT scan of the thorax within the last 12 months
* Pregnant women
* Unable to provide consent
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Manchester

OTHER

Sponsor Role collaborator

The Christie NHS Foundation Trust

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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The Christie NHS Foundation Trust

Manchester, , United Kingdom

Site Status

Countries

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United Kingdom

References

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Broadbent R, Crosbie P, Armitage CJ, Taylor B, Tenant S, Mercer J, Radford J, Linton K. Pilot study of lung cancer screening for survivors of Hodgkin lymphoma. Haematologica. 2024 Oct 1;109(10):3305-3313. doi: 10.3324/haematol.2023.283287.

Reference Type DERIVED
PMID: 37981893 (View on PubMed)

Other Identifiers

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CFTSp204

Identifier Type: -

Identifier Source: org_study_id

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