Carpal Tunnel Syndrome, Right/Left Judgement

NCT ID: NCT04967144

Last Updated: 2022-02-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-07-19

Study Completion Date

2021-12-30

Brief Summary

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The discrimination of the right/left side of the body is related to the integrity of the motor and somatosensory areas at the cortical and subcortical levels. Although some studies have shown that there may be an effect on the right/left representation at the cortical and subcortical levels in cases that cause severe neuropathy and neuropathic pain, this effect has not been proven in milder neuropathies. In this study, the effect on right/left side discrimination will be investigated even in cases with carpal tunnel syndrome. Additionally, the investigators aimed to assess the relationship between right/left discrimination and symptom severity.

Detailed Description

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The left/right discrimination is a motor imagery task that involves viewing images of a body part and determining whether each image belongs to the left or right side of the body or if it rotates towards it. Some studies have shown that there may be an effect on the right/left representation at the cortical and subcortical levels in cases that cause severe neuropathy and neuropathic pain, this effect has not been proven in milder neuropathies, such as carpal tunnel syndrome. In this study, the relationship between right/left decision accuracy will be compared with control subjects. The investigators will assess the relationship between right/left judgment and symptom severity, two-point discrimination, and handgrip force.

The hypothesis of the study are:

1. The right/left discrimination accuracy is less than the control subjects.
2. Right/left discrimination is in relationship with symptom severity, two-point discrimination, and handgrip force.

Conditions

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Carpal Tunnel Syndrome

Study Design

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Observational Model Type

COHORT

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Carpal Tunnel syndrome

.Patients with carpal tunnel syndrome

Nerve conduction study

Intervention Type DIAGNOSTIC_TEST

Participants with carpal tunnel syndrome will consist of individuals whose diagnosis has been confirmed by an electrophysiological study.

Participants in the control group will consist of those who have been confirmed not to have carpal tunnel syndrome by nerve conduction study.

Montreal Cognitive Assessment Test

Intervention Type DIAGNOSTIC_TEST

Montreal Cognitive Assessment Test evaluates eight separate cognitive functions. Thirty is the highest score. The scores equal to or above 26 are considered normal cognitive function.

Control subjects

Healthy subjects

Nerve conduction study

Intervention Type DIAGNOSTIC_TEST

Participants with carpal tunnel syndrome will consist of individuals whose diagnosis has been confirmed by an electrophysiological study.

Participants in the control group will consist of those who have been confirmed not to have carpal tunnel syndrome by nerve conduction study.

Montreal Cognitive Assessment Test

Intervention Type DIAGNOSTIC_TEST

Montreal Cognitive Assessment Test evaluates eight separate cognitive functions. Thirty is the highest score. The scores equal to or above 26 are considered normal cognitive function.

Interventions

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Nerve conduction study

Participants with carpal tunnel syndrome will consist of individuals whose diagnosis has been confirmed by an electrophysiological study.

Participants in the control group will consist of those who have been confirmed not to have carpal tunnel syndrome by nerve conduction study.

Intervention Type DIAGNOSTIC_TEST

Montreal Cognitive Assessment Test

Montreal Cognitive Assessment Test evaluates eight separate cognitive functions. Thirty is the highest score. The scores equal to or above 26 are considered normal cognitive function.

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Participants with a duration of symptoms associated with unilateral CTS of at least 3 months
* Participants with clinically and nerve conduction study confirmed carpal tunnel syndrome
* All participants will be right-hand dominance and diagnosed with carpal tunnel syndrome on the same side
* Participants with MOCA score minimum 26.

Exclusion Criteria

* Severe visual impairment that may prevent performing the test
* Polyneuropathy
* Cervical spine surgery history
* Presence of abnormal cervical spine, shoulder, and elbow joint examination findings
* Patients with any history of surgery for the upper extremity
* Congenital/Developmental upper extremity malformations
* Central nervous system disease
* Antihistaminic, gabapentinoids, antiepileptics, methylphenidate, modafinil, neuroleptics use
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Bozyaka Training and Research Hospital

OTHER

Sponsor Role lead

Responsible Party

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Şeniz Akçay

Study Director

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Seniz Akcay, Assoc Prof

Role: STUDY_DIRECTOR

University of Health Sciences Izmir Bozyaka Training and Research Hospital

Altinay Goksel Karatepe, Prof

Role: STUDY_CHAIR

University of Health Sciences Izmir Bozyaka Training and Research Hospital

Fikriye Elif Saka, MD

Role: STUDY_CHAIR

University of Health Sciences Izmir Bozyaka Training and Research Hospital

Asli Koskderelioglu, Assoc Prof

Role: STUDY_CHAIR

University of Health Sciences Izmir Bozyaka Training and Research Hospital

Neslihan Eskut, Specialist

Role: STUDY_CHAIR

University of Health Sciences Izmir Bozyaka Training and Research Hospital

Locations

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University of Health Sciences Izmir Bozyaka Training and Research Hospital

Izmir, Karabaglar, Turkey (Türkiye)

Site Status

Countries

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Turkey (Türkiye)

References

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Breckenridge JD, Ginn KA, Wallwork SB, McAuley JH. Do People With Chronic Musculoskeletal Pain Have Impaired Motor Imagery? A Meta-analytical Systematic Review of the Left/Right Judgment Task. J Pain. 2019 Feb;20(2):119-132. doi: 10.1016/j.jpain.2018.07.004. Epub 2018 Aug 9.

Reference Type BACKGROUND
PMID: 30098404 (View on PubMed)

Schmid AB, Coppieters MW. Left/right judgment of body parts is selectively impaired in patients with unilateral carpal tunnel syndrome. Clin J Pain. 2012 Sep;28(7):615-22. doi: 10.1097/AJP.0b013e31823e16b9.

Reference Type RESULT
PMID: 22688599 (View on PubMed)

Moseley GL. Why do people with complex regional pain syndrome take longer to recognize their affected hand? Neurology. 2004 Jun 22;62(12):2182-6. doi: 10.1212/01.wnl.0000130156.05828.43.

Reference Type RESULT
PMID: 15210879 (View on PubMed)

Williams LJ, Braithwaite FA, Leake HB, McDonnell MN, Peto DK, Lorimer Moseley G, Hillier SL. Reliability and validity of a mobile tablet for assessing left/right judgements. Musculoskelet Sci Pract. 2019 Apr;40:45-52. doi: 10.1016/j.msksp.2019.01.010. Epub 2019 Jan 24.

Reference Type RESULT
PMID: 30703633 (View on PubMed)

Akcay S, Koskderelioglu A, Ince B, Elif Saka F, Eskut N, Goksel Karatepe A. Is the left/right judgment task performance altered in unilateral carpal tunnel syndrome: And associated with symptom severity? Musculoskelet Sci Pract. 2022 Dec;62:102641. doi: 10.1016/j.msksp.2022.102641. Epub 2022 Aug 4.

Reference Type DERIVED
PMID: 35961062 (View on PubMed)

Other Identifiers

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2021/40

Identifier Type: -

Identifier Source: org_study_id

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