Refeeding Like Syndrome in Acute Disease

NCT ID: NCT04966780

Last Updated: 2021-07-26

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 48 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2018-04-01
• Study Completion Date: 2021-06-01

Brief Summary

The refeeding syndrome has been reported without any evidence of prolopnged semistarvation, thus being different from the traditional disease.

The investigators wanted to investigate, if sodium infusions could be part of the explanation.

Detailed Description

Background: Refeeding syndrome is conventionally connected to start of feeding after prolonged periods of semi-starvation and adaption. However, it is also described in acutely ill patients and in ICU patients without a history of adaption, but sometimes only defined as a drop in p-phosphate without clinical manifestations. The investigators hypothesize, that a positive sodium balance could induce the refeeding-like syndrome (RLS).

Method: Consecutive patients for acute, abdominal surgery were included and observed until discharge or up to seven days postoperatively with daily sodium and phosphate balance measurements.

Conditions

Refeeding Syndrome; Acute Abdomen

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Interventions

acute abdominal surgery

Acute surgery for acute abdominal disease

Intervention Type: PROCEDURE

Eligibility Criteria

Inclusion Criteria

• age > 18 yr
• ready for acute surgery
• able to understand and cooperate.

Exclusion Criteria

• pregnancy or breastfeeding
• renal insufficiency (p-creatinine>400 micr mol/l)
• re-operations
• expected hospital stay < 24 hours.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

University of Copenhagen

OTHER

Sponsor Role: collaborator

Jens Rikardt Andersen

OTHER

Sponsor Role: lead

Responsible Party

Jens Rikardt Andersen

Associate Professor, Primary Investigator

Responsibility Role: SPONSOR_INVESTIGATOR

Principal Investigators

jens R Andersen

Role: PRINCIPAL_INVESTIGATOR

University of Copenhagen

Locations

Herlev University Hospital

Herlev, , Denmark

Countries

Denmark

Other Identifiers

RLS in surgery

Identifier Type: -

Identifier Source: org_study_id