Neurobiomarker for Prism Adaptation Treatment Response

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

WITHDRAWN

Clinical Phase

NA

Study Classification

INTERVENTIONAL

Study Start Date

2023-01-01

Study Completion Date

2024-12-05

Brief Summary

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Preliminary data will be collected about which individuals with spatial neglect from right hemisphere stroke (aiming vs perceptual neglect) improve with Prism Adaptation Training and if there is a particular pattern of damage in the brain that predicts both the type of neglect experienced and whether neglect is improved following Prism Adaptation Training

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Detailed Description

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For preliminary data, twelve individuals with right hemisphere stroke and spatial neglect will participate. After pretesting for type of neglect and its severity, they will have an MRI with Diffusion Tensor Imaging (DTI). Then they will complete 10 sessions of Prism Adaptation Therapy and complete neglect post-testing. Response to Prism Adaptation Therapy will be assessed by comparing neglect scores pre- and post-training. Traditional lesion mapping, structural and functional lesion disconnectivity analyses, and tract-based spatial statistics of DTI measures will be used to examine whether any patterns of damage/dysfunction are related to a diagnosis of aiming neglect and response to Prism Adaptation Therapy.

Conditions

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Perceptual Disorders Stroke Biomarker

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

a single group pre-post pilot study

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Prism Adaptation Therapy

10 sessions (60 trials each) 1x/day of Prism Adaptation Therapy

Group Type EXPERIMENTAL

Prism Adaptation Therapy

Intervention Type BEHAVIORAL

Participants wear goggles with built-in prisms (a 20-diopter lens) that shift the visual scene to the right. While wearing the googles they reach to and cross out 60 lines/circles, requiring them to learn to reach more leftward than the visual targets appear. Participants can only see the end of their movements.

Interventions

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Prism Adaptation Therapy

Participants wear goggles with built-in prisms (a 20-diopter lens) that shift the visual scene to the right. While wearing the googles they reach to and cross out 60 lines/circles, requiring them to learn to reach more leftward than the visual targets appear. Participants can only see the end of their movements.

Intervention Type BEHAVIORAL

Other Intervention Names

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PAT

Eligibility Criteria

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Inclusion Criteria

* 1\) within 1 month of right hemisphere stroke

2\) suspected of having unilateral spatial neglect

3\) able to provide consent

4\) likely to remain in rehabilitation for 10-12 days or willing to return to the University to complete 10 sessions of treatment and post-treatment testing

5\) able to have an MRI

6\) will be or has been admitted to the Craig H. Neilson Rehabilitation Hospital for rehabilitation or is able to come to the Craig H. Neilson Rehabilitation Hospital for prism adaptation therapy sessions.

7\) age 18-90 years

8\) able to sit in a wheelchair or other chair for 1 hour

9\) able to point straight ahead and hold a pen with right hand

Exclusion Criteria

* 1\) other neurologic, medical that would interfere with ability to complete the testing or training

2\) no uncorrected visual or hearing problems, other than hemianopsia

3\) contraindications to MRI

4\) unable to provide consent due to significant aphasia or cognitive impairment

Minimum Eligible Age

18 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No