Multicenter Study on the Pathogenic Germline Gene Variants of Colorectal Polyposis in China

NCT ID: NCT04961125

Last Updated: 2021-07-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-08-02

Study Completion Date

2024-12-31

Brief Summary

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Patients suspected of adenomatous polyposis were included. The criteria used were more than 10 polyps observed under colonoscopy, and pathological confirmation of adenoma. Clinical data and pedigree information were collected. The variants of 139 genes associated with different hereditary cancers and polyposis were screened by NGS, which was performed by Genetron Health on the HiSeqX-ten sequencing platform.

Detailed Description

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Conditions

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Colorectal Polyposis

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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colorectal polyposis

germline variants

Intervention Type GENETIC

Variants of 139 genes associated with different hereditary cancers and polyposis were screened by next-generation sequencing.

Interventions

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germline variants

Variants of 139 genes associated with different hereditary cancers and polyposis were screened by next-generation sequencing.

Intervention Type GENETIC

Eligibility Criteria

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Inclusion Criteria

1. clinical diagnosis of adenomatous polyposis;
2. enough samples (provide at least 5ml of peripheral whole blood) for germline variant detection

Exclusion Criteria

genetic diagnosis of polyposis syndrome
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Second Affiliated Hospital, School of Medicine, Zhejiang University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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General Hospital of Air Force

Beijing, Beijing Municipality, China

Site Status RECRUITING

The Sixth Affiliated Hospital of Sun Yat-sen University

Guangzhou, Guangdong, China

Site Status RECRUITING

Jiangsu Province Hospital

Nanjing, Jiangsu, China

Site Status RECRUITING

Zhejiang Cancer Hospital

Hangzhou, Zhejiang, China

Site Status RECRUITING

SAHZU

Hangzhou, Zhejinag, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Ying Yuan, PhD

Role: CONTACT

86-13858193601

Dong Xu, PhD

Role: CONTACT

86-13858191696

Facility Contacts

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Guoli Gu, MD

Role: primary

Daici Chen, PhD

Role: primary

Yanhong Gu, MD

Role: primary

Haixing Ju, MD

Role: primary

Ying Yuan, Ph.D & MD

Role: primary

Ying Yuan

Role: backup

Other Identifiers

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2017-072

Identifier Type: -

Identifier Source: org_study_id

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