Dexmedetpmidine Versus Ketamine for Postoperative Sore Throat in Sinus Surgery

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

143 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-08-19

Study Completion Date

2023-02-15

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The aim of this randomized clinical trial is to evaluate the impact of dexmedetomidine versus ketamine soaked pharyngeal packing on postoperative sore throat in functional endoscopic sinus surgery (FESS).

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

A Comparative Study to Measure the Effect of Nebulized Dexmedetomidine

NCT05158348

Dexmedetomidine Lidocaine Tonsillectomy

UNKNOWN PHASE3

Efficacy of Peritonsillar Dexmedetomidine Infiltration for Postadenotonsillectomy Pain

NCT02013570

Pain Postoperative, Intraoperative Hemorrhage

COMPLETED PHASE4

The Effect of Peritonsillar Infiltration of Ketamine and Dexamethasone for Postoperative Pain Relief in Children Following Adenotonsillectomy

NCT01198210

Tonsillectomy

UNKNOWN PHASE1/PHASE2

Topical Ketamine Analgesia in Children Undergoing Tonsillectomy: a Clinical and Serum Level Assays Study.

NCT02720406

Postoperative Pain

COMPLETED PHASE2/PHASE3

Evaluation of the Efficacy of Preoperative Ketamine Nebulization on Postoperative Sore Throat Due to Tracheal Intubation for Adult Patients Under General Anesthesia, A Prospective Randomized Controlled Study

NCT05975346

Post Operative Sore Throat

UNKNOWN

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

A written informed consent was taken from the patients.patients will be randomly assigned to three groups of 40 subjects each; dexmedetomidine or ketamine or saline soaked pharyngeal packs were situated under direct vision. Throat packs made of gauze with a length of 20 cm and a width of 10 cm (folded transverse four times) and medications were diluted with 20 ml normal saline. The packings were placed by the surgeon blinded to the study groups.

1-Dexmedetomidine group: 75 µg dexmedetomidine soaked pharyngeal pack (Group D) putted in the posterior pharyngeal wall after induction of anesthesia and \& endotracheal tube (ETT).

2-Ketamine group: 50 mg ketamine soaked pharyngeal pack (Group K) putted in the posterior pharyngeal wall after induction of anesthesia and ETT.

3-Control group: 20 ml 0.9% saline soaked pharyngeal pack (Group C) putted in the posterior pharyngeal wall after induction of anesthesia and ETT.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Sore Throat

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Caregivers

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Dexmedetomidine

75 µg dexmedetomidine soaked pharyngeal pack

Group Type EXPERIMENTAL

Dexmedetomidine

Intervention Type DRUG

75 µg dexmedetomidine soaked pharyngeal pack (Group D) putted in the posterior pharyngeal wall after induction of anesthesia and ETT.

Ketamine

50 mg ketamine soaked pharyngeal pack

Group Type EXPERIMENTAL

Ketamine

Intervention Type DRUG

50 mg ketamine soaked pharyngeal pack (Group K) putted in the posterior pharyngeal wall after induction of anesthesia and ETT.

Saline placebo

20 ml 0.9% saline soaked pharyngeal pack

Group Type EXPERIMENTAL

saline 0.9%

Intervention Type OTHER

20 ml 0.9% saline soaked pharyngeal pack (Group C) putted in the posterior pharyngeal wall after induction of anesthesia and ETT.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Dexmedetomidine

75 µg dexmedetomidine soaked pharyngeal pack (Group D) putted in the posterior pharyngeal wall after induction of anesthesia and ETT.

Intervention Type DRUG

Ketamine

50 mg ketamine soaked pharyngeal pack (Group K) putted in the posterior pharyngeal wall after induction of anesthesia and ETT.

Intervention Type DRUG

saline 0.9%

20 ml 0.9% saline soaked pharyngeal pack (Group C) putted in the posterior pharyngeal wall after induction of anesthesia and ETT.

Intervention Type OTHER

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

Precedex ketalar Normal saline

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Adults of both sex with American Society of Anesthesiologists (ASA) physical status I-II
* Elective functional endoscopic sinus surgery (FESS) with endotracheal intubation.

Exclusion Criteria

* A history of preoperative sore throat.
* Upper respiratory tract illness
* Potentially difficult airway
* Patients with history of neck, respiratory or digestive tract pathology
* Chronic smokers
* Using steroid within the last 48 hour
* Pregnant women

Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No